Reactome | p-S473-AKT1 phosphorylates ESR1 on serine-167

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p-S473-AKT1 phosphorylates ESR1 on serine-167 Show undefined attributes

authored	[InstanceEdit:9841259] May, Bruce, 2023-08-09
catalystActivity	[CatalystActivity:9841246] protein serine kinase activity of p-S473-AKT1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9841260] May, Bruce, 2023-08-11
dbId	9841265
displayName	p-S473-AKT1 phosphorylates ESR1 on serine-167
edited	[InstanceEdit:9841259] May, Bruce, 2023-08-09
eventOf	[Pathway:R-HSA-9841251] Mitochondrial unfolded protein response (UPRmt) - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9841817] p-S167-ESR1 translocates from the cytosol to the nucleus - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-9841939] ESR1 dimer [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9841261] Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance [LiteratureReference:9841262] Estrogen receptor mediates a distinct mitochondrial unfolded protein response
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	p-S473-AKT1 phosphorylates ESR1 on serine-167
orthologousEvent	[Reaction:R-DME-9841265] p-S473-AKT1 phosphorylates ESR1 on serine-167 - Drosophila melanogaster [Reaction:R-GGA-9841265] p-S473-AKT1 phosphorylates ESR1 on serine-167 - Gallus gallus [Reaction:R-DRE-9841265] p-S473-AKT1 phosphorylates ESR1 on serine-167 - Danio rerio [Reaction:R-RNO-9841265] p-S473-AKT1 phosphorylates ESR1 on serine-167 - Rattus norvegicus [Reaction:R-MMU-9841265] p-S473-AKT1 phosphorylates ESR1 on serine-167 - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-9841941] p-S167-ESR1 dimer [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9841244] Phosphorylation of AKT1 on serine-473 in response to reactive oxygen species - Homo sapiens
releaseDate	2024-09-11
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9841265
summation	[Summation:9841850] In response to an accumulation of unfolded protein in the mi...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-9841817] p-S167-ESR1 translocates from the cytosol to the nucleus
(hasEvent)	[Pathway:R-HSA-9841251] Mitochondrial unfolded protein response (UPRmt)

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