p-S473-AKT1 phosphorylates ESR1 on serine-167

Stable Identifier
R-HSA-9841265
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
3/5
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p-S473-AKT1 phosphorylates ESR1 on serine-167
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In response to an accumulation of unfolded protein in the mitochondrial intermembrane space, the kinase AKT is activated by phosphorylation through an uncharacterized mechanism, and phosphorylates estrogen receptor alpha (ESR1) (Papa and Germain 2011) on serine-167 (Campbell et al. 2001, Papa and Germain 2011).
Literature References
PubMed ID Title Journal Year
11139588 Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance

Patel, NM, Nakshatri, H, Ali, S, Campbell, RA, Constantinidou, D, Bhat-Nakshatri, P

J Biol Chem 2001
21486948 Estrogen receptor mediates a distinct mitochondrial unfolded protein response

Papa, L, Germain, D

J Cell Sci 2011
Participants
Input
Output
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as an event of
Catalyst Activity

protein serine kinase activity of p-S473-AKT1 [cytosol]

Physical Entity
p-S473-AKT1 [cytosol] (Homo sapiens)
Activity
protein serine kinase activity (GO:0106310)
Orthologous Events
p-S473-AKT1 phosphorylates ESR1 on serine-167 (Danio rerio)
p-S473-AKT1 phosphorylates ESR1 on serine-167 (Drosophila melanogaster)
p-S473-AKT1 phosphorylates ESR1 on serine-167 (Gallus gallus)
p-S473-AKT1 phosphorylates ESR1 on serine-167 (Mus musculus)
p-S473-AKT1 phosphorylates ESR1 on serine-167 (Rattus norvegicus)
Authored
May, B  (2023-08-09)
Created
May, B  (2023-08-11)
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