Reactome | YME1L1 degrades mitochondrial intermembrane space proteins

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YME1L1 degrades mitochondrial intermembrane space proteins Show undefined attributes

authored	[InstanceEdit:9839796] May, Bruce, 2023-07-09
catalystActivity	[CatalystActivity:9840193] ATP-dependent peptidase activity of YME1L1:substrate protein (mitochondrial intermembrane space) [mitochondrial inner membrane]
category	uncertain
compartment	[Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:9839776] May, Bruce, 2023-07-10
dbId	9839751
displayName	YME1L1 degrades mitochondrial intermembrane space proteins
edited	[InstanceEdit:9839796] May, Bruce, 2023-07-09
eventOf	[Pathway:R-HSA-9837999] Mitochondrial protein degradation - Homo sapiens
inferredFrom	[BlackBoxEvent:R-SCE-9839836] YME1 degrades TIM10 - Saccharomyces cerevisiae
input	[SimpleEntity:R-ALL-5696069] ATP [mitochondrial intermembrane space] [SimpleEntity:R-ALL-189422] H2O [mitochondrial intermembrane space] [Complex:R-HSA-9839792] YME1L1:substrate protein (mitochondrial intermembrane space) [mitochondrial inner membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9839768] Lipid signalling drives proteolytic rewiring of mitochondria by YME1L [LiteratureReference:6801241] TRIAP1/PRELI complexes prevent apoptosis by mediating intramitochondrial transport of phosphatidic acid [LiteratureReference:9839793] PARL partitions the lipid transfer protein STARD7 between the cytosol and mitochondria [LiteratureReference:9852678] Mitochondrial Nuclear Retrograde Regulator 1 (MNRR1) rescues the cellular phenotype of MELAS by inducing homeostatic mechanisms
maxDepth	1
modified	[InstanceEdit:9852714] May, Bruce, 2023-11-06
name	YME1L1 degrades mitochondrial intermembrane space proteins
output	[SimpleEntity:R-ALL-5696026] ADP [mitochondrial intermembrane space] [SimpleEntity:R-ALL-9839058] Pi [mitochondrial intermembrane space] [Complex:R-HSA-9839129] YME1L1:Zn2+ hexamer [mitochondrial inner membrane]
precedingEvent	[Reaction:R-HSA-9839772] YME1L1 binds mitochondrial intermembrane space proteins - Homo sapiens
releaseDate	2023-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9852695] Aljghami, Mazen E, 2023-11-04 [InstanceEdit:9852696] Houry, Walid A, 2023-11-04 [InstanceEdit:9852693] Morey, Trevor, 2023-11-04
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9839751
summation	[Summation:9839800] YME1L1 (YME1L, i-AAA) is a hexameric metalloprotease that is...

Referrals

(hasEvent)	[Pathway:R-HSA-9837999] Mitochondrial protein degradation
(inferredTo)	[BlackBoxEvent:R-SCE-9839836] YME1 degrades TIM10

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