Reactome | p-PKR dimer phosphorylates ILF3:ILF2

Schema > Reaction > Entries

p-PKR dimer phosphorylates ILF3:ILF2 Show undefined attributes

authored	[InstanceEdit:9836352] Stephan, Ralf, 2023-05-26
catalystActivity	[CatalystActivity:9835964] protein kinase activity of p-EIF2AK2 dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9836394] Stephan, Ralf, 2023-05-27
dbId	9836383
displayName	p-PKR dimer phosphorylates ILF3:ILF2
edited	[InstanceEdit:9841954] Stephan, Ralf, 2023-08-16
eventOf	[Pathway:R-HSA-9833482] PKR-mediated signaling - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-9836384] ILF2:ILF3 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9836382] DRBP76, a double-stranded RNA-binding nuclear protein, is phosphorylated by the interferon-induced protein kinase, PKR [LiteratureReference:9836389] DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45 [LiteratureReference:9834789] Phosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase PKR constitutes a novel mechanism of translational regulation and cellular defense
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	p-PKR dimer phosphorylates ILF3:ILF2
orthologousEvent	[Reaction:R-CEL-9836383] p-PKR dimer phosphorylates ILF3:ILF2 - Caenorhabditis elegans [Reaction:R-DME-9836383] p-PKR dimer phosphorylates ILF3:ILF2 - Drosophila melanogaster [Reaction:R-XTR-9836383] p-PKR dimer phosphorylates ILF3:ILF2 - Xenopus tropicalis [Reaction:R-DRE-9836383] p-PKR dimer phosphorylates ILF3:ILF2 - Danio rerio [Reaction:R-SSC-9836383] p-PKR dimer phosphorylates ILF3:ILF2 - Sus scrofa [Reaction:R-BTA-9836383] p-PKR dimer phosphorylates ILF3:ILF2 - Bos taurus [Reaction:R-CFA-9836383] p-PKR dimer phosphorylates ILF3:ILF2 - Canis familiaris [Reaction:R-RNO-9836383] p-PKR dimer phosphorylates ILF3:ILF2 - Rattus norvegicus [Reaction:R-MMU-9836383] p-PKR dimer phosphorylates ILF3:ILF2 - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-9836392] ILF2 [cytosol] [EntityWithAccessionedSequence:R-HSA-9836381] p-T188,T315-ILF3 [cytosol]
precedingEvent	[Reaction:R-HSA-9833820] PKR dimer autophosphorylates - Homo sapiens
releaseDate	2023-09-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9841953] Patel, Rekha C, 2023-08-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9836383
summation	[Summation:9836386] Activated PKR phosphorylates interleukin enhancer-binding fa...

Referrals

(hasEvent)

[Pathway:R-HSA-9833482] PKR-mediated signaling