Reactome | p-PKR dimer phosphorylates ILF3:ILF2

p-PKR dimer phosphorylates ILF3:ILF2

Stable Identifier

R-HSA-9836383

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Activated PKR phosphorylates interleukin enhancer-binding factor 3 (also known as NF90, NFAR, DRBP76, MBP4, or ILF3) at residues T188 and T315, resulting in dissociation of p-ILF3 from its complex with ILF2, retaining and accumulating p-ILF3 in the cytosol. On viral infection, cytosolic p-ILF3 binds to viral mRNA, inhibiting its translation. Since ILF3 also activates PKR, both processes appear to be part of a feedback loop, enhancing PKR signaling (Ting et al, 1998; Patel et al, 1999; Harashima et al, 2010).

Literature References

PubMed ID	Title	Journal	Year
10400669	DRBP76, a double-stranded RNA-binding nuclear protein, is phosphorylated by the interferon-induced protein kinase, PKR Patel, RC, Vestal, DJ, Xu, Z, Bandyopadhyay, S, Guo, W, Erme, SM, Williams, BR, Sen, GC	J Biol Chem	1999
21123651	Phosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase PKR constitutes a novel mechanism of translational regulation and cellular defense Harashima, A, Guettouche, T, Barber, GN	Genes Dev	2010
9442054	DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45 Ting, NS, Kao, PN, Chan, DW, Lintott, LG, Lees-Miller, SP	J Biol Chem	1998