Reactome | Formation of the NSL complex

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Formation of the NSL complex Show undefined attributes

authored	[InstanceEdit:9823562] Orlic-Milacic, Marija, 2023-01-06
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9828180] Orlic-Milacic, Marija, 2023-02-10
dbId	9828175
displayName	Formation of the NSL complex
edited	[InstanceEdit:9828330] Orlic-Milacic, Marija, 2023-02-13
eventOf	[Pathway:R-HSA-9772755] Formation of WDR5-containing histone-modifying complexes - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-HSA-1592209] HCFC1 [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-HSA-3321875] KANSL1 [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-HSA-3321796] KANSL2 [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-HSA-3321882] KANSL3 [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-HSA-3321802] KAT8 [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-HSA-3321849] MCRS1 [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-HSA-3321845] OGT [nucleoplasm] [DefinedSet:R-HSA-9828236] PHF20, PHF20L1 [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-HSA-1629838] WDR5 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3321809] A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16 [LiteratureReference:3321879] Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex [LiteratureReference:9828186] Methyl-lysine readers PHF20 and PHF20L1 define two distinct�gene expression-regulating NSL complexes [LiteratureReference:9770965] Crosstalk between NSL histone acetyltransferase and MLL/SET complexes: NSL complex functions in promoting histone H3K4 di-methylation activity by MLL/SET complexes [LiteratureReference:9828167] Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis [LiteratureReference:9828177] PHF20 Readers Link Methylation of Histone H3K4 and p53 with H4K16 Acetylation
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Formation of the NSL complex
orthologousEvent	[Reaction:R-DME-9828175] Formation of the NSL complex - Drosophila melanogaster [Reaction:R-BTA-9828175] Formation of the NSL complex - Bos taurus [Reaction:R-CFA-9828175] Formation of the NSL complex - Canis familiaris [Reaction:R-RNO-9828175] Formation of the NSL complex - Rattus norvegicus [Reaction:R-MMU-9828175] Formation of the NSL complex - Mus musculus
output	[DefinedSet:R-HSA-9828237] NSL [nucleoplasm]
releaseDate	2023-03-29
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9827909] Van, Hieu, 2023-02-08 [InstanceEdit:9827910] Ge, Kai, 2023-02-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9828175
summation	[Summation:9828172] WDR5 is a subunit of an evolutionarily conserved lysine acet...

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[Pathway:R-HSA-9772755] Formation of WDR5-containing histone-modifying complexes

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