Reactome | Formation of the NSL complex

Formation of the NSL complex

Stable Identifier

R-HSA-9828175

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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WDR5 is a subunit of an evolutionarily conserved lysine acetyltransferase Non-Specific-Lethal (NSL) complex together with the following proteins: KAT8 (also known as MOF) as the catalytic subunit, KANSL1-3 (also known as NSL1-3), MCRS1, HCFC1 (also known as Host cell factor 1 or HCF1), and one of the paralogous proteins: PHF20 or PHF20-like 1 (PHF20L1) (Smith et al, 2005; Cai et al, 2010; Van et al 2022). The NSL complex is responsible for the acetylation of lysine K5, K8, K12, and K16 of histone H4 (Smith et al, 2005; Cai et al, 2010; Zhao et al, 2013; Radzisheuskaya et al., 2021). The NSL complex binds to the promoters of house-keeping genes and regulates their expression (Radzisheuskaya et al., 2021), therefore in some contexts, it is essential for the viability and proliferation of human cells (Klein et al, 2016; Radzisheuskaya et al., 2021).

Literature References

PubMed ID	Title	Journal	Year
35033534	Methyl-lysine readers PHF20 and PHF20L1 define two distinct gene expression-regulating NSL complexes Lu, Y, Jain, AK, Van, HT, Bedford, MT, Santos, MA, Patel, A, Harkins, PR	J Biol Chem	2022
20018852	Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex Choi, SH, Cai, Y, Conaway, RC, Florens, LA, Conaway, JW, Swanson, SK, Cole, MD, Washburn, MP, Jin, J	J. Biol. Chem.	2010
27760318	PHF20 Readers Link Methylation of Histone H3K4 and p53 with H4K16 Acetylation Wang, X, Cui, G, Mer, G, Lu, Y, Kutateladze, TG, Klein, BJ, Shi, X, Yuan, C, Wang, X, Bruns, CJ, Zhao, Y, Lin, K, Botuyan, MV	Cell Rep	2016
16227571	A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16 Lane, WS, Smith, ER, Côté, J, Huang, R, Cayrou, C, Lucchesi, JC	Mol. Cell. Biol.	2005
33657400	Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis Helin, K, Hendrickson, RC, Gorshkov, V, Jensen, ON, Johnstone, AL, Kovalchuk, S, Grinev, VV, Zhan, Y, Rodriguez, KL, Shliaha, PV, Radzisheuskaya, A, Shlyueva, D, Koche, R, Keogh, MC, Damhofer, H	Mol Cell	2021
24244196	Crosstalk between NSL histone acetyltransferase and MLL/SET complexes: NSL complex functions in promoting histone H3K4 di-methylation activity by MLL/SET complexes Cai, Y, Wu, M, Conaway, RC, Yang, Y, Jin, J, Cao, L, Liu, D, Ding, J, Conaway, JW, Wu, D, Wang, F, Zhao, X, Su, J	PLoS Genet	2013