Reactome | SNAI2 and TBX3 repress CDH1 gene expression during melanocyte development

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SNAI2 and TBX3 repress CDH1 gene expression during melanocyte development Show undefined attributes

authored	[InstanceEdit:9825798] Rothfels, Karen, 2023-01-26
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:876] plasma membrane
created	[InstanceEdit:9825775] Rothfels, Karen, 2023-01-26
dbId	9825774
displayName	SNAI2 and TBX3 repress CDH1 gene expression during melanocyte development
edited	[InstanceEdit:9825798] Rothfels, Karen, 2023-01-26
eventOf	[Pathway:R-HSA-9856649] Transcriptional and post-translational regulation of MITF-M expression and activity - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9756422] CDH1 gene [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9825360] N-cadherin-mediated intercellular interactions promote survival and migration of melanoma cells [LiteratureReference:9825374] The melanocyte differentiation program predisposes to metastasis after neoplastic transformation [LiteratureReference:9825366] Snail-related transcriptional repressors are required in Xenopus for both the induction of the neural crest and its subsequent migration [LiteratureReference:9730389] The melanocyte lineage in development and disease [LiteratureReference:9756421] The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression [LiteratureReference:9730375] Melanocytes in development, regeneration, and cancer [LiteratureReference:9857452] Calreticulin represses E-cadherin gene expression in Madin-Darby canine kidney cells via Slug [LiteratureReference:9857455] SYT-SSX1 and SYT-SSX2 interfere with repression of E-cadherin by snail and slug: a potential mechanism for aberrant mesenchymal to epithelial transition in human synovial sarcoma [LiteratureReference:9768562] The SLUG zinc-finger protein represses E-cadherin in breast cancer [LiteratureReference:9857311] Role of T-box genes in cancer, epithelial-mesenchymal transition, and cancer stem cells [LiteratureReference:9768259] Tbx3 represses E-cadherin expression and enhances melanoma invasiveness [LiteratureReference:9825391] Endothelin B receptor blockade inhibits dynamics of cell interactions and communications in melanoma cell progression
maxDepth	1
modified	[InstanceEdit:9927682] Rothfels, Karen, 2024-11-08
name	SNAI2 and TBX3 repress CDH1 gene expression during melanocyte development
output	[EntityWithAccessionedSequence:R-HSA-198003] CDH1(155-882) [plasma membrane]
precedingEvent	[Reaction:R-HSA-9768533] SNAI2 binds CDH1 gene promoter - Homo sapiens [Reaction:R-HSA-9825776] p-S742 TBX3 binds ID1 promoter - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[NegativeGeneExpressionRegulation:9796544] Negative gene expression regulation by 'SNAI2:CDH1 gene [nucleoplasm]' [NegativeGeneExpressionRegulation:9825739] Negative gene expression regulation by 'p-S742 TBX3:CDH1 gene [nucleoplasm]' [NegativeGeneExpressionRegulation:9907128] Negative gene expression regulation by 'EDN1, EDN3:EDNRB [plasma membrane]'
regulationReference	[RegulationReference:9825763] Negative gene expression regulation by 'CDH1 gene:p-S742 TBX3 [nucleoplasm]' Tbx3 represses E-cadherin expression and enhances melanoma invasiveness [RegulationReference:9907137] Negative gene expression regulation by 'SNAI2:CDH1 gene [nucleoplasm]' SYT-SSX1 and SYT-SSX2 interfere with repression of E-cadherin by snail and slug: a potential mechanism for aberrant mesenchymal to epithelial transition in human synovial sarcoma [RegulationReference:9907134] Negative gene expression regulation by 'EDN1, EDN3:EDNRB [plasma membrane]' Endothelin B receptor blockade inhibits dynamics of cell interactions and communications in melanoma cell progression
releaseDate	2024-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9910860] de la Serna, Ivana L, 2024-05-21 [InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05 [InstanceEdit:9927252] Steingr�msson, Eir�kur, 2024-11-05
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9825774
summation	[Summation:9857457] Changes in relative levels of E- and N-cadherin contribute t...

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[Pathway:R-HSA-9856649] Transcriptional and post-translational regulation of MITF-M expression and activity

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