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Schema
>
Reaction
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Entries
CHUK, IKBKB phosphorylate RIPK1 at S25
Show undefined attributes
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authored
[InstanceEdit:9818053] Shamovsky, Veronica, 2022-10-10
catalystActivity
[CatalystActivity:9820495] protein serine/threonine kinase activity of TNF?:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane]
catalystActivityReference
[CatalystActivityReference:9820497] protein serine/threonine kinase activity of TNF?:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created
[InstanceEdit:9818788] Shamovsky, Veronica, 2022-10-20
dbId
9818789
displayName
CHUK, IKBKB phosphorylate RIPK1 at S25
edited
[InstanceEdit:9818840] Shamovsky, Veronica, 2022-10-24
eventOf
[Pathway:R-HSA-5357905] Regulation of TNFR1 signaling - Homo sapiens
input
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[Complex:R-HSA-9818787] TNF?:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9698252] Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation
[LiteratureReference:9698245] NF-?B-Independent Role of IKK?/IKK? in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling
maxDepth
1
modified
[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
name
CHUK, IKBKB phosphorylate RIPK1 at S25
orthologousEvent
[Reaction:R-DRE-9818789] CHUK, IKBKB phosphorylate RIPK1 at S25 - Danio rerio
[Reaction:R-SSC-9818789] CHUK, IKBKB phosphorylate RIPK1 at S25 - Sus scrofa
[Reaction:R-BTA-9818789] CHUK, IKBKB phosphorylate RIPK1 at S25 - Bos taurus
[Reaction:R-CFA-9818789] CHUK, IKBKB phosphorylate RIPK1 at S25 - Canis familiaris
[Reaction:R-RNO-9818789] CHUK, IKBKB phosphorylate RIPK1 at S25 - Rattus norvegicus
[Reaction:R-MMU-9818789] CHUK, IKBKB phosphorylate RIPK1 at S25 - Mus musculus
output
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[Complex:R-HSA-9818791] TNF?:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane]
releaseDate
2022-12-07
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9818965] Tu, Hailin, 2022-10-31
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9818789
summation
[Summation:9818792] Binding of TNF? to TNF receptor 1 (TNFR1) induces the sequen...
Referrals
(hasEvent)
[Pathway:R-HSA-5357905] Regulation of TNFR1 signaling
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