Reactome | CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex

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CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex Show undefined attributes

authored	[InstanceEdit:9818053] Shamovsky, Veronica, 2022-10-10
catalystActivity	[CatalystActivity:9818831] K63-linked deubiquitinase activity of TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9818966] Lys63-specific deubiquitinase activity of TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9817364] Shamovsky, Veronica, 2022-09-16
dbId	9817400
displayName	CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex
edited	[InstanceEdit:9818840] Shamovsky, Veronica, 2022-10-24
eventOf	[Pathway:R-HSA-5357905] Regulation of TNFR1 signaling - Homo sapiens
input	[Complex:R-HSA-9817363] TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5357806] Regulation of NF-?B by deubiquitinases [LiteratureReference:5357741] CYLD deubiquitinates RIP1 in the TNF?-induced necrosome to facilitate kinase activation and programmed necrosis
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex
orthologousEvent	[BlackBoxEvent:R-SSC-9817400] CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex - Sus scrofa [BlackBoxEvent:R-BTA-9817400] CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex - Bos taurus [BlackBoxEvent:R-CFA-9817400] CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex - Canis familiaris [BlackBoxEvent:R-RNO-9817400] CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex - Rattus norvegicus [BlackBoxEvent:R-MMU-9817400] CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex - Mus musculus
output	[CandidateSet:R-HSA-5357900] BIRC2,3,4 [cytosol] [Complex:R-HSA-9796690] CYLD:SPATA2:LUBAC [cytosol] [Complex:R-HSA-140946] TNF-?:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] [DefinedSet:R-HSA-113595] Ub [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9817362] SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-5357923] Negative regulation by 'p-S418-CYLD [cytosol]'
releaseDate	2022-12-07
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9818965] Tu, Hailin, 2022-10-31
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9817400
summation	[Summation:9817393] Binding of TNF? to TNF receptor 1 (TNFR1) induces the sequen...

Referrals

(hasEvent)

[Pathway:R-HSA-5357905] Regulation of TNFR1 signaling