Reactome | DUX4 binds HERVL LTR

Schema > Reaction > Entries

DUX4 binds HERVL LTR Show undefined attributes

authored	[InstanceEdit:9817262] May, Bruce, 2022-09-13
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9817247] May, Bruce, 2022-09-15
dbId	9817289
displayName	DUX4 binds HERVL LTR
edited	[InstanceEdit:9817262] May, Bruce, 2022-09-13
eventOf	[Pathway:R-HSA-9819196] Zygotic genome activation (ZGA) - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9816412] DUX4 [nucleoplasm] [GenomeEncodedEntity:R-HSA-9817294] HERVL LTR [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9816444] Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons [LiteratureReference:9817253] DUX4 binding to retroelements creates promoters that are active in FSHD muscle and testis [LiteratureReference:9816414] DUX-family transcription factors regulate zygotic genome activation in placental mammals [LiteratureReference:9817242] DUX4 is a multifunctional factor priming human embryonic genome activation
maxDepth	1
modified	[InstanceEdit:9841067] May, Bruce, 2023-08-08
name	DUX4 binds HERVL LTR
output	[Complex:R-HSA-9817285] DUX4:HERVL LTR [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9816369] Expression of DUX4 in the zygote - Homo sapiens
releaseDate	2023-09-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9841065] Xie, Wei, 2023-08-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9817289
summation	[Summation:9817267] DUX4 binds thousands of LTRs of human endogenous retrovirus-...

Referrals

(hasEvent)

[Pathway:R-HSA-9819196] Zygotic genome activation (ZGA)

Cite Us!