DUX4 binds HERVL LTR

Stable Identifier
R-HSA-9817289
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
DUX4 binds HERVL LTR
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
DUX4 binds thousands of LTRs of human endogenous retrovirus-like (HERV-like) retrotransposons, notably the leucine-tRNA primed HERVL family, and MLT2A solo LTRs (Young et al. 2013, De Iaco et al. 2017, Hendrickson et al. 2017, Vuoristo et al. 2022). DUX4 activates bidirectional transcription of the retroelements (Vuoristo et al. 2022), which peaks in cleavage stage embryos (Hendrickson et al. 2017). Many of the LTR elements serve as alternative promoters for genes activated during zygotic genome activation (Young et al. 2013).
Literature References
PubMed ID Title Journal Year
35402882 DUX4 is a multifunctional factor priming human embryonic genome activation

Kirjanov, I, Murakawa, Y, Katayama, S, Weltner, J, Recher, G, Nykänen, S, Johnson, MS, Huhtala, M, Lundin, K, Krjutškov, K, Otonkoski, T, Jouhilahti, EM, Paluoja, P, Hashimoto, K, Tamirat, M, Paloviita, P, Kere, J, Hydén-Granskog, C, Varjosalo, M, Tapanainen, JS, Takegami, Y, Damdimopoulos, A, Bhagat, S, Yoshihara, M, Vuoristo, S, Ranga, V, Tuuri, T, Ezer, S, Airenne, TT, Kawaji, H, Bürglin, TR, Gawriyski, L, Kanemaru, A

iScience 2022
28459456 DUX-family transcription factors regulate zygotic genome activation in placental mammals

Duc, J, De Iaco, A, Coluccio, A, Verp, S, Planet, E, Trono, D

Nat Genet 2017
28459457 Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons

Peterson, CM, Lim, JW, Cairns, BR, Pflueger, C, Tapscott, SJ, Wike, CL, Grow, EJ, Hendrickson, PG, Carrell, DT, Nix, DA, Whiddon, JL, Emery, BR, Wilcox, AL, Weaver, BD, Doráis, JA

Nat Genet 2017
24278031 DUX4 binding to retroelements creates promoters that are active in FSHD muscle and testis

Balog, J, Snider, L, Tawil, R, Whiddon, JL, van der Maarel, SM, Geng, LN, Tapscott, SJ, Young, JM, Kasinathan, B, Yao, Z

PLoS Genet 2013
Participants
Input
Output
Participates
as an event of
Authored
May, B  (2022-09-13)
Reviewed
Xie, W  (2023-08-08)
Created
May, B  (2022-09-15)
Cite Us!