Reactome | DUX4, TPRXL, TPRX1, and TPRX2 bind the DUXA gene

Schema > Reaction > Entries

authored	[InstanceEdit:9817262] May, Bruce, 2022-09-13
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9817247] May, Bruce, 2022-09-15
dbId	9817269
displayName	DUX4, TPRXL, TPRX1, and TPRX2 bind the DUXA gene
edited	[InstanceEdit:9817262] May, Bruce, 2022-09-13
eventOf	[Pathway:R-HSA-9819196] Zygotic genome activation (ZGA) - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9817940] Expression of DUXA in the embryo - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9816412] DUX4 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9817245] DUXA gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9816444] Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons [LiteratureReference:9816414] DUX-family transcription factors regulate zygotic genome activation in placental mammals
maxDepth	1
modified	[InstanceEdit:9841067] May, Bruce, 2023-08-08
name	DUX4, TPRXL, TPRX1, and TPRX2 bind the DUXA gene
output	[Complex:R-HSA-9817243] DUX4:DUXA gene [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9816369] Expression of DUX4 in the zygote - Homo sapiens
releaseDate	2023-09-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9841065] Xie, Wei, 2023-08-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9817269
summation	[Summation:9820766] DUX4 binds the DUXA gene (Hendrickson et al. 2017) near the ...

(precedingEvent)	[BlackBoxEvent:R-HSA-9817940] Expression of DUXA in the embryo
(hasEvent)	[Pathway:R-HSA-9819196] Zygotic genome activation (ZGA)

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