DUX4, TPRXL, TPRX1, and TPRX2 bind the DUXA gene

Stable Identifier
R-HSA-9817269
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
DUX4, TPRXL, TPRX1, and TPRX2 bind the DUXA gene
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
DUX4 binds the DUXA gene (Hendrickson et al. 2017) near the transcription start site (De Iaco et al. 2017). TPRXL, TPRX1, and TPRX2 also positively regulate the DUXA gene (Zou et al. 2022).
Literature References
PubMed ID Title Journal Year
28459456 DUX-family transcription factors regulate zygotic genome activation in placental mammals

De Iaco, A, Planet, E, Coluccio, A, Verp, S, Duc, J, Trono, D

Nat Genet 2017
28459457 Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons

Hendrickson, PG, Doráis, JA, Grow, EJ, Whiddon, JL, Lim, JW, Wike, CL, Weaver, BD, Pflueger, C, Emery, BR, Wilcox, AL, Nix, DA, Peterson, CM, Tapscott, SJ, Carrell, DT, Cairns, BR

Nat Genet 2017
Participants
Input
Output
Participates
as an event of
Authored
May, B  (2022-09-13)
Reviewed
Xie, W  (2023-08-08)
Created
May, B  (2022-09-15)
Cite Us!