DUX4, TPRXL, TPRX1, and TPRX2 bind the DUXA gene

Stable Identifier
R-HSA-9817269
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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DUX4, TPRXL, TPRX1, and TPRX2 bind the DUXA gene
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DUX4 binds the DUXA gene (Hendrickson et al. 2017) near the transcription start site (De Iaco et al. 2017). TPRXL, TPRX1, and TPRX2 also positively regulate the DUXA gene (Zou et al. 2022).
Literature References
PubMed ID Title Journal Year
28459456 DUX-family transcription factors regulate zygotic genome activation in placental mammals

Duc, J, De Iaco, A, Coluccio, A, Verp, S, Planet, E, Trono, D

Nat Genet 2017
28459457 Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons

Peterson, CM, Lim, JW, Cairns, BR, Pflueger, C, Tapscott, SJ, Wike, CL, Grow, EJ, Hendrickson, PG, Carrell, DT, Nix, DA, Whiddon, JL, Emery, BR, Wilcox, AL, Weaver, BD, Doráis, JA

Nat Genet 2017
Participants
Input
Output
Participates
as an event of
Authored
May, B  (2022-09-13)
Reviewed
Xie, W  (2023-08-08)
Created
May, B  (2022-09-15)
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