Reactome | SLCO1A2 transports Cipro(1+) into the cytosol

Schema > Reaction > Entries

SLCO1A2 transports Cipro(1+) into the cytosol Show undefined attributes

authored	[InstanceEdit:9794261] Stephan, Ralf, 2022-07-01
catalystActivity	[CatalystActivity:9794405] transmembrane transporter activity of SLCO1A2 [apical plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:70101] cytosol [Compartment:24781] apical plasma membrane
created	[InstanceEdit:9794264] Stephan, Ralf, 2022-07-01
dbId	9794270
displayName	SLCO1A2 transports Cipro(1+) into the cytosol
edited	[InstanceEdit:9795211] Stephan, Ralf, 2022-08-01
eventOf	[Pathway:R-HSA-9793528] Ciprofloxacin ADME - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9794414] Basolateral transport of Cipro to extracellular space - Homo sapiens
input	[SimpleEntity:R-ALL-9793566] Cipro(1+) [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9794269] Oral drug delivery utilizing intestinal OATP transporters [LiteratureReference:9794263] Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells [LiteratureReference:9794265] Identification of influx transporter for the quinolone antibacterial agent levofloxacin
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	SLCO1A2 transports Cipro(1+) into the cytosol
orthologousEvent	[Reaction:R-CEL-9794270] SLCO1A2 transports Cipro(1+) into the cytosol - Caenorhabditis elegans [Reaction:R-DME-9794270] SLCO1A2 transports Cipro(1+) into the cytosol - Drosophila melanogaster [Reaction:R-GGA-9794270] SLCO1A2 transports Cipro(1+) into the cytosol - Gallus gallus [Reaction:R-DRE-9794270] SLCO1A2 transports Cipro(1+) into the cytosol - Danio rerio [Reaction:R-SSC-9794270] SLCO1A2 transports Cipro(1+) into the cytosol - Sus scrofa [Reaction:R-BTA-9794270] SLCO1A2 transports Cipro(1+) into the cytosol - Bos taurus [Reaction:R-CFA-9794270] SLCO1A2 transports Cipro(1+) into the cytosol - Canis familiaris [Reaction:R-RNO-9794270] SLCO1A2 transports Cipro(1+) into the cytosol - Rattus norvegicus [Reaction:R-MMU-9794270] SLCO1A2 transports Cipro(1+) into the cytosol - Mus musculus
output	[SimpleEntity:R-ALL-9793625] Cipro [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9793564] Cipro HCl dissolves - Homo sapiens
releaseDate	2022-12-07
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9820563] Thorn, Caroline F, 2022-11-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9794270
summation	[Summation:9794268] Transport protein SLCO1A2 (organic anion transporting polype...

Referrals

(hasEvent)	[Pathway:R-HSA-9793528] Ciprofloxacin ADME
(precedingEvent)	[BlackBoxEvent:R-HSA-9794414] Basolateral transport of Cipro to extracellular space