SLCO1A2 transports Cipro(1+) into the cytosol

Stable Identifier
R-HSA-9794270
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, cytosol, apical plasma membrane
ReviewStatus
5/5
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SLCO1A2 transports Cipro(1+) into the cytosol
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Transport protein SLCO1A2 (organic anion transporting polypeptide 1A2, OATP1A2, OATP-A) is localized at the apical membrane of human small intestinal epithelial cells (Su et al, 2004). Inhibition studies in a Caco-2 cell line subclone suggest that Cipro(1+) is at least partly imported by SLCO1A2 from the GI lumen (Maeda et al, 2007; reviewed in Tamai, 2011).
Literature References
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Output
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as an event of
Catalyst Activity

organic cation transmembrane transporter activity of SLCO1A2 [apical plasma membrane ]

Physical Entity
SLCO1A2 [apical plasma membrane] (Homo sapiens)
Activity
organic cation transmembrane transporter activity (GO:0015101)
Orthologous Events
SLCO1A2 transports Cipro(1+) into the cytosol (Bos taurus)
SLCO1A2 transports Cipro(1+) into the cytosol (Caenorhabditis elegans)
SLCO1A2 transports Cipro(1+) into the cytosol (Canis familiaris)
SLCO1A2 transports Cipro(1+) into the cytosol (Danio rerio)
SLCO1A2 transports Cipro(1+) into the cytosol (Drosophila melanogaster)
SLCO1A2 transports Cipro(1+) into the cytosol (Gallus gallus)
SLCO1A2 transports Cipro(1+) into the cytosol (Mus musculus)
SLCO1A2 transports Cipro(1+) into the cytosol (Rattus norvegicus)
SLCO1A2 transports Cipro(1+) into the cytosol (Sus scrofa)
Authored
Stephan, R  (2022-07-01)
Reviewed
Thorn, CF  (2022-11-09)
Created
Stephan, R  (2022-07-01)
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