Reactome | ABCG2 transports Cipro from intestinal cell to extracellular space

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ABCG2 transports Cipro from intestinal cell to extracellular space Show undefined attributes

authored	[InstanceEdit:9793698] Stephan, Ralf, 2022-06-23
catalystActivity	[CatalystActivity:9794400] ATPase-coupled transmembrane transporter activity of ABCG2 tetramer [apical plasma membrane ]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:9794138] Stephan, Ralf, 2022-06-27
dbId	9794120
displayName	ABCG2 transports Cipro from intestinal cell to extracellular space
edited	[InstanceEdit:9795211] Stephan, Ralf, 2022-08-01
eventOf	[Pathway:R-HSA-9793528] Ciprofloxacin ADME - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-9793625] Cipro [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9794133] Intestinal ciprofloxacin efflux: the role of breast cancer resistance protein (ABCG2) [LiteratureReference:9794125] Multiple pathways for fluoroquinolone secretion by human intestinal epithelial (Caco-2) cells [LiteratureReference:9794134] Fluoroquinolone (ciprofloxacin) secretion by human intestinal epithelial (Caco-2) cells [LiteratureReference:9794117] Fluoroquinolone efflux mediated by ABC transporters [LiteratureReference:9794422] Expression, localization, and functional characteristics of breast cancer resistance protein in Caco-2 cells
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	ABCG2 transports Cipro from intestinal cell to extracellular space
orthologousEvent	[Reaction:R-PFA-9794120] ABCG2 transports Cipro from intestinal cell to extracellular space - Plasmodium falciparum [Reaction:R-DDI-9794120] ABCG2 transports Cipro from intestinal cell to extracellular space - Dictyostelium discoideum [Reaction:R-CEL-9794120] ABCG2 transports Cipro from intestinal cell to extracellular space - Caenorhabditis elegans [Reaction:R-DME-9794120] ABCG2 transports Cipro from intestinal cell to extracellular space - Drosophila melanogaster [Reaction:R-XTR-9794120] ABCG2 transports Cipro from intestinal cell to extracellular space - Xenopus tropicalis [Reaction:R-SSC-9794120] ABCG2 transports Cipro from intestinal cell to extracellular space - Sus scrofa [Reaction:R-BTA-9794120] ABCG2 transports Cipro from intestinal cell to extracellular space - Bos taurus [Reaction:R-CFA-9794120] ABCG2 transports Cipro from intestinal cell to extracellular space - Canis familiaris [Reaction:R-RNO-9794120] ABCG2 transports Cipro from intestinal cell to extracellular space - Rattus norvegicus [Reaction:R-MMU-9794120] ABCG2 transports Cipro from intestinal cell to extracellular space - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-9794119] Cipro [extracellular region] [SimpleEntity:R-ALL-1524165] PI [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9794352] Basolateral transport of Cipro into intestinal cell - Homo sapiens
releaseDate	2022-12-07
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9820563] Thorn, Caroline F, 2022-11-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9794120
summation	[Summation:9794260] Inhibition studies with Caco-2 cells show there may be a num...

Referrals

(hasEvent)

[Pathway:R-HSA-9793528] Ciprofloxacin ADME