ABCG2 transports Cipro from intestinal cell to extracellular space

Stable Identifier
R-HSA-9794120
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, extracellular region
ReviewStatus
5/5
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ABCG2 transports Cipro from intestinal cell to extracellular space
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Inhibition studies with Caco-2 cells show there may be a number of transport proteins involved in the transport of ciprofloxacin (Cipro) through GI cells (Cavet et al, 1997). Secretion of Cipro into the GI lumen involves two distinct transport steps: at the basolateral cell membrane, Cipro is accumulated within the cytosol, with secretion then occurring across the apical membrane (Lowes & Simmons, 2002; Xia et al, 2005; Haslam et al, 2011; reviewed by Alvarez et al, 2008). The importance of this process relative to the main excretion pathways (renal and biliary) is unclear, however.
Literature References
PubMed ID Title Journal Year
11877335 Multiple pathways for fluoroquinolone secretion by human intestinal epithelial (Caco-2) cells

Lowes, S, Simmons, NL

Br J Pharmacol 2002
15716365 Expression, localization, and functional characteristics of breast cancer resistance protein in Caco-2 cells

Xia, CQ, Liu, N, Yang, D, Miwa, G, Gan, LS

Drug Metab Dispos 2005
9283689 Fluoroquinolone (ciprofloxacin) secretion by human intestinal epithelial (Caco-2) cells

Cavet, ME, West, M, Simmons, NL

Br J Pharmacol 1997
18200507 Fluoroquinolone efflux mediated by ABC transporters

Alvarez, AI, Pérez, M, Prieto, JG, Molina, AJ, Real, R, Merino, G

J Pharm Sci 2008
21930826 Intestinal ciprofloxacin efflux: the role of breast cancer resistance protein (ABCG2)

Haslam, IS, Wright, JA, O'Reilly, DA, Sherlock, DJ, Coleman, T, Simmons, NL

Drug Metab Dispos 2011
Participants
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Output
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as an event of
Catalyst Activity

ATPase-coupled transmembrane transporter activity of ABCG2 tetramer [apical plasma membrane ]

Physical Entity
ABCG2 tetramer [apical plasma membrane] (Homo sapiens)
Activity
ATPase-coupled transmembrane transporter activity (GO:0042626)
Orthologous Events
ABCG2 transports Cipro from intestinal cell to extracellular space (Bos taurus)
ABCG2 transports Cipro from intestinal cell to extracellular space (Caenorhabditis elegans)
ABCG2 transports Cipro from intestinal cell to extracellular space (Canis familiaris)
ABCG2 transports Cipro from intestinal cell to extracellular space (Dictyostelium discoideum)
ABCG2 transports Cipro from intestinal cell to extracellular space (Drosophila melanogaster)
ABCG2 transports Cipro from intestinal cell to extracellular space (Mus musculus)
ABCG2 transports Cipro from intestinal cell to extracellular space (Plasmodium falciparum)
ABCG2 transports Cipro from intestinal cell to extracellular space (Rattus norvegicus)
ABCG2 transports Cipro from intestinal cell to extracellular space (Saccharomyces cerevisiae)
ABCG2 transports Cipro from intestinal cell to extracellular space (Sus scrofa)
ABCG2 transports Cipro from intestinal cell to extracellular space (Xenopus tropicalis)
Authored
Stephan, R  (2022-06-23)
Reviewed
Thorn, CF  (2022-11-09)
Created
Stephan, R  (2022-06-27)
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