Reactome | Displacement of C2a/Bb by CR1

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Displacement of C2a/Bb by CR1 Show undefined attributes

authored	[InstanceEdit:981647] Jupe, S, 2010-10-26
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:977612] Jupe, S, 2010-10-20
dbId	977629
displayName	Displacement of C2a/Bb by CR1
edited	[InstanceEdit:983442] Jupe, S, 2010-11-01
eventOf	[Pathway:R-HSA-977606] Regulation of Complement cascade - Homo sapiens
followingEvent	[Reaction:R-HSA-977602] Complement factor I binds to MCP, CR1:C4b, C3b - Homo sapiens
input	[DefinedSet:R-HSA-981676] CR1:C3bBb, C4bC2a complexes [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:977358] Regulation of the amplification C3 convertase of human complement by an inhibitory protein isolated from human erythrocyte membrane [LiteratureReference:981672] Decay-accelerating factor (DAF), complement receptor 1 (CR1), and factor H dissociate the complement AP C3 convertase (C3bBb) via sites on the type A domain of Bb [LiteratureReference:1006147] Decay accelerating activity of complement receptor type 1 (CD35). Two active sites are required for dissociating C5 convertases
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	Displacement of C2a/Bb by CR1
orthologousEvent	[Reaction:R-GGA-2530591] CREG (CR1L) causes dissociation of C3 convertases - Gallus gallus [Reaction:R-SSC-977629] Displacement of C2a/Bb by CR1 - Sus scrofa [Reaction:R-CFA-977629] Displacement of C2a/Bb by CR1 - Canis familiaris [Reaction:R-MMU-977629] Displacement of C2a/Bb by CR1 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-166780] C2a [extracellular region] [EntityWithAccessionedSequence:R-HSA-182453] CFB(260-764) [extracellular region] [Complex:R-HSA-981635] CR1:C3b [plasma membrane] [Complex:R-HSA-981675] CR1:C4b [plasma membrane]
precedingEvent	[Reaction:R-HSA-977375] CR1 binds C3bBb/C4bC2a - Homo sapiens
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2109568] Bradley, DT, 2012-02-13 [InstanceEdit:2109566] Fraczek, LA, 2012-02-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-977629
summation	[Summation:981671] Complement Receptor 1 (CR1) displaces the activated enzyme c...

Referrals

(hasEvent)	[Pathway:R-HSA-977606] Regulation of Complement cascade
(precedingEvent)	[Reaction:R-HSA-977602] Complement factor I binds to MCP, CR1:C4b, C3b