Reactome | PHGDH tetramer dehydrogenates 3PG

Schema > Reaction > Entries

PHGDH tetramer dehydrogenates 3PG Show undefined attributes

authored	[InstanceEdit:977335] Stephan, R, 2010-10-16
catalystActivity	[CatalystActivity:977334] phosphoglycerate dehydrogenase activity of PHGDH tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:977325] Jassal, B, 2010-10-18
crossReference	[DatabaseIdentifier:12667568] RHEA:12642 [DatabaseIdentifier:9929446] RHEA:12642
dbId	977348
displayName	PHGDH tetramer dehydrogenates 3PG
edited	[InstanceEdit:977325] Jassal, B, 2010-10-18
eventOf	[Pathway:R-HSA-977347] Serine metabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-977333] PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA - Homo sapiens [Reaction:R-HSA-9856871] MDH1 reduces OA - Homo sapiens
input	[SimpleEntity:R-ALL-29728] 3PG [cytosol] [SimpleEntity:R-ALL-29360] NAD+ [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:977338] Novel mutations in 3-phosphoglycerate dehydrogenase (PHGDH) are distributed throughout the protein and result in altered enzyme kinetics
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	PHGDH tetramer dehydrogenates 3PG (2R)-3-phosphoglycerate + NAD(+) => 3-phosphooxypyruvate + H(+) + NADH 3-phosphoglycerate is dehydrogenated
orthologousEvent	[Reaction:R-MMU-977348] PHGDH tetramer dehydrogenates 3PG - Mus musculus [Reaction:R-CEL-977348] PHGDH tetramer dehydrogenates 3PG - Caenorhabditis elegans [Reaction:R-DME-977348] PHGDH tetramer dehydrogenates 3PG - Drosophila melanogaster [Reaction:R-GGA-977348] PHGDH tetramer dehydrogenates 3PG - Gallus gallus [Reaction:R-XTR-977348] PHGDH tetramer dehydrogenates 3PG - Xenopus tropicalis [Reaction:R-DRE-977348] PHGDH tetramer dehydrogenates 3PG - Danio rerio [Reaction:R-SSC-977348] PHGDH tetramer dehydrogenates 3PG - Sus scrofa [Reaction:R-BTA-977348] PHGDH tetramer dehydrogenates 3PG - Bos taurus [Reaction:R-CFA-977348] PHGDH tetramer dehydrogenates 3PG - Canis familiaris [Reaction:R-RNO-977348] PHGDH tetramer dehydrogenates 3PG - Rattus norvegicus
output	[SimpleEntity:R-ALL-977329] 3POPA [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-73473] NADH [cytosol]
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1828027] D'Eustachio, P, 2011-10-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-977348
summation	[Summation:977405] Serine biosynthesis starts from 3-phosphoglycerate (3PG), a ...
updateTrackers	[UpdateTracker:9777668] Update Tracker - [Reaction:977348] PHGDH tetramer dehydrogenates 3PG - v69:[modifyText] [UpdateTracker:9775437] Update Tracker - [Reaction:977348] PHGDH tetramer dehydrogenates 3PG - v79:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9777668] Update Tracker - [Reaction:977348] PHGDH tetramer dehydrogenates 3PG - v69:[modifyText] [UpdateTracker:9775437] Update Tracker - [Reaction:977348] PHGDH tetramer dehydrogenates 3PG - v79:[modifyText]
(hasEvent)	[Pathway:R-HSA-977347] Serine metabolism
(precedingEvent)	[Reaction:R-HSA-977333] PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA [Reaction:R-HSA-9856871] MDH1 reduces OA

Cite Us!