Reactome | BRCA2 mutants do not bind SEM1 (DSS1)

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BRCA2 mutants do not bind SEM1 (DSS1) Show undefined attributes

authored	[InstanceEdit:9763685] Orlic-Milacic, Marija, 2022-01-26
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9763196] Orlic-Milacic, Marija, 2022-01-31
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9763200
disease	[Disease:1500689] cancer
displayName	BRCA2 mutants do not bind SEM1 (DSS1)
edited	[InstanceEdit:9763742] Orlic-Milacic, Marija, 2022-02-04
entityFunctionalStatus	[EntityFunctionalStatus:9763199] loss_of_function and partial_loss_of_function of BRCA2 mutants (SEM1 binding) [cytosol]
eventOf	[Pathway:R-HSA-9763198] Impaired BRCA2 binding to SEM1 (DSS1) - Homo sapiens
input	[CandidateSet:R-HSA-9763197] BRCA2 mutants (SEM1 binding) [cytosol] [EntityWithAccessionedSequence:R-HSA-8866674] SEM1 [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9763147] Cancer-causing BRCA2 missense mutations disrupt an intracellular protein assembly mechanism to disable genome maintenance
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	BRCA2 mutants do not bind SEM1 (DSS1)
normalReaction	[Reaction:R-HSA-9763137] BRCA2 binds SEM1 (DSS1)
releaseDate	2022-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9763679] Liu, Jie, 2022-01-26 [InstanceEdit:9763678] Le, Hang Phuong, 2022-01-26 [InstanceEdit:9763681] Heyer, Wolf-Dietrich, 2022-01-26
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9763200
summation	[Summation:9763206] Several BRCA2 cancer-derived missense mutations within the S...

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(hasEvent)

[Pathway:R-HSA-9763198] Impaired BRCA2 binding to SEM1 (DSS1)

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