Reactome | Ub,pS335,S338,T NFE2L2 is degraded

Schema > BlackBoxEvent > Entries

Ub,pS335,S338,T NFE2L2 is degraded Show undefined attributes

authored	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
catalystActivity	[CatalystActivity:174087] endopeptidase activity of 26S proteasome [nucleoplasm]
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9762099] Rothfels, Karen, 2022-01-17
dbId	9762096
displayName	Ub,pS335,S338,T NFE2L2 is degraded
edited	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
eventOf	[Pathway:R-HSA-9762114] GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 - Homo sapiens
input	[Complex:R-HSA-9762077] BTRC:SKP1:CUL1:RBX1:ub,p-S335, S338 NFE2L2 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9761995] SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner [LiteratureReference:9762014] Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/?-TrCP axis [LiteratureReference:9708494] The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway [LiteratureReference:9762027] The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Ub,pS335,S338,T NFE2L2 is degraded
orthologousEvent	[BlackBoxEvent:R-PFA-9762096] Ub,pS335,S338,T NFE2L2 is degraded - Plasmodium falciparum [BlackBoxEvent:R-CEL-9762096] Ub,pS335,S338,T NFE2L2 is degraded - Caenorhabditis elegans [BlackBoxEvent:R-DME-9762096] Ub,pS335,S338,T NFE2L2 is degraded - Drosophila melanogaster [BlackBoxEvent:R-GGA-9762096] Ub,pS335,S338,T NFE2L2 is degraded - Gallus gallus [BlackBoxEvent:R-XTR-9762096] Ub,pS335,S338,T NFE2L2 is degraded - Xenopus tropicalis [BlackBoxEvent:R-DRE-9762096] Ub,pS335,S338,T NFE2L2 is degraded - Danio rerio [BlackBoxEvent:R-BTA-9762096] Ub,pS335,S338,T NFE2L2 is degraded - Bos taurus [BlackBoxEvent:R-CFA-9762096] Ub,pS335,S338,T NFE2L2 is degraded - Canis familiaris [BlackBoxEvent:R-RNO-9762096] Ub,pS335,S338,T NFE2L2 is degraded - Rattus norvegicus [BlackBoxEvent:R-MMU-9762096] Ub,pS335,S338,T NFE2L2 is degraded - Mus musculus
output	[Complex:R-HSA-9762080] BTRC:SKP1:RBX1:CUL1 [nucleoplasm] [DefinedSet:R-HSA-68524] Ub [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9762091] NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 - Homo sapiens
releaseDate	2022-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9762096
summation	[Summation:9762068] After BTRC:CUL1-mediated ubiquitination, NFE2L2 is degraded ...

Referrals

(hasEvent)	[Pathway:R-HSA-9762114] GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
(precedingEvent)	[NegativePrecedingEvent:9767157] Futile Cycle: Ub,pS335,S338,T NFE2L2 is degraded