Reactome | Ub,pS335,S338,T NFE2L2 is degraded

Schema > BlackBoxEvent > Entries

Ub,pS335,S338,T NFE2L2 is degraded Show undefined attributes

catalystActivity	[CatalystActivity:10560135] endopeptidase activity of 26S proteasome [nucleoplasm]
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10641895
displayName	Ub,pS335,S338,T NFE2L2 is degraded
eventOf	[Pathway:R-DRE-9762114] GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-9762096] Ub,pS335,S338,T NFE2L2 is degraded - Homo sapiens
input	[Complex:R-DRE-9762077] BTRC:SKP1:CUL1:RBX1:ub,p-S335, S338 NFE2L2 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Ub,pS335,S338,T NFE2L2 is degraded
output	[Complex:R-DRE-9762080] BTRC:SKP1:RBX1:CUL1 [nucleoplasm] [DefinedSet:R-DRE-68524] Ub [nucleoplasm]
precedingEvent	[Reaction:R-DRE-9762091] NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 - Danio rerio
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:68323] Danio rerio
stId	R-DRE-9762096
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-9762114] GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
(inferredTo)	[BlackBoxEvent:R-HSA-9762096] Ub,pS335,S338,T NFE2L2 is degraded

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