Reactome | AcK-NFE2L2-dependent P6GD gene expression

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AcK-NFE2L2-dependent P6GD gene expression Show undefined attributes

authored	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9761842] Rothfels, Karen, 2022-01-15
dbId	9761849
displayName	AcK-NFE2L2-dependent P6GD gene expression
edited	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
eventOf	[Pathway:R-HSA-9818028] NFE2L2 regulates pentose phosphate pathway genes - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9761730] G6PD gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9761654] The Role of the Pentose Phosphate Pathway in Diabetes and Cancer [LiteratureReference:9761640] Oxidative Stress in Cancer [LiteratureReference:9708494] The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway [LiteratureReference:9759995] Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray [LiteratureReference:9759273] Beneficial role of Nrf2 in regulating NADPH generation and consumption [LiteratureReference:9761612] Nrf2-MafG heterodimers contribute globally to antioxidant and metabolic networks [LiteratureReference:9761603] Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	AcK-NFE2L2-dependent P6GD gene expression
output	[DefinedSet:R-HSA-464971] G6PD dimer and tetramer [cytosol]
precedingEvent	[Reaction:R-HSA-9761812] AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:9761855] Positive gene expression regulation by 'G6PD gene:p-AcK-NFE2L2:CREBBP,EP300:MAFG [nucleoplasm]'
regulationReference	[RegulationReference:9761853] Positive gene expression regulation by 'P6GD gene:p-AcK-NFE2L2:CREBBP,EP300:MAFG [nucleoplasm]' Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming
releaseDate	2022-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9761849
summation	[Summation:9761770] Glucose-6-phosphate dehydrogenase (G6PD) catalyzes the first...

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[Pathway:R-HSA-9818028] NFE2L2 regulates pentose phosphate pathway genes