Reactome | SecA:SecYEG transports proteins from cytosol to periplasmic space

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SecA:SecYEG transports proteins from cytosol to periplasmic space Show undefined attributes

authored	[InstanceEdit:9760315] Stephan, Ralf, 2021-12-16
catalystActivity	[CatalystActivity:9760318] protein-exporting ATPase activity of SecA:SecYEG [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:1222638] periplasmic space [Compartment:876] plasma membrane
created	[InstanceEdit:9760325] Stephan, Ralf, 2021-12-16
crossReference	[DatabaseIdentifier:12020761] Mondo:0005113
dbId	9760310
deleted	[Deleted:9912379] Deletion of instance: 9760596 [Deleted:9949964] Deletion of instance: 9760596 [Deleted:9912377] Deletion of instance: 9760599 [Deleted:9949963] Deletion of instance: 9760599
disease	[Disease:3134792] bacterial infectious disease
displayName	SecA:SecYEG transports proteins from cytosol to periplasmic space
edited	[InstanceEdit:9948470] Stephan, Ralf, 2025-05-21
eventOf	[Pathway:R-HSA-9760173] Secretion of toxins - Homo sapiens
followingEvent	[Reaction:R-HSA-9912368] LepB cleaves pre-EltA - Homo sapiens [Reaction:R-HSA-9912371] LepB cleaves pre-EltB - Homo sapiens [Reaction:R-HSA-9911383] LepB cleaves prepro-STa - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [DefinedSet:R-ECO-9912286] Sec translocase cargo [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9760324] The complete general secretory pathway in gram-negative bacteria [LiteratureReference:9760321] Structural and Mechanistic Insights into Protein Translocation [LiteratureReference:9912294] Energy transduction in protein transport and the ATP hydrolytic cycle of SecA
maxDepth	1
modified	[InstanceEdit:9948469] Stephan, Ralf, 2025-05-21
name	SecA:SecYEG transports proteins from cytosol to periplasmic space
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol] [DefinedSet:R-ECO-9912292] Sec translocase cargo [periplasmic space]
relatedSpecies	[Species:159879] Escherichia coli
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9760310
summation	[Summation:9760736] The Sec family of protein transmembrane transport complexes ...

Referrals

(replacementInstances)	[Deleted:9912379] Deletion of instance: 9760596 [Deleted:9949964] Deletion of instance: 9760596 [Deleted:9912377] Deletion of instance: 9760599 [Deleted:9949963] Deletion of instance: 9760599
(precedingEvent)	[Reaction:R-HSA-9912368] LepB cleaves pre-EltA [Reaction:R-HSA-9912371] LepB cleaves pre-EltB [Reaction:R-HSA-9911383] LepB cleaves prepro-STa
(hasEvent)	[Pathway:R-HSA-9760173] Secretion of toxins

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