Reactome | AcK-NFE2L2 and MAFK bind the GSTA1 gene

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AcK-NFE2L2 and MAFK bind the GSTA1 gene Show undefined attributes

authored	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9760096] Rothfels, Karen, 2021-12-14
dbId	9760097
displayName	AcK-NFE2L2 and MAFK bind the GSTA1 gene
edited	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
eventOf	[Pathway:R-HSA-9818027] NFE2L2 regulating anti-oxidant/detoxification enzymes - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9760128] AcK-NFE2L2-dependent GSTA1 gene expression - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9760038] GSTA1 gene [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-1008242] MAFK [nucleoplasm] [Complex:R-HSA-9760062] p-AcK-NFE2L2:CREBBP, EP300 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9758970] An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements [LiteratureReference:9759995] Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray [LiteratureReference:9759989] Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response [LiteratureReference:9708494] The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway [LiteratureReference:9760007] The multifaceted role of glutathione S-transferases in cancer
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	AcK-NFE2L2 and MAFK bind the GSTA1 gene
output	[Complex:R-HSA-9760078] GSTA1 gene:p-AcK-NFE2L2:MAFK:CREBBP, EP300 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9760081] CREBBP, EP300 acetylates NFE2L2 - Homo sapiens [Reaction:R-HSA-9708557] FBXL17 binds BACH1:MAFK - Homo sapiens
releaseDate	2022-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9760097
summation	[Summation:9760052] Phosphorylated, acetylated NFE2L2 binds to the antioxidant r...

Referrals

(hasEvent)	[Pathway:R-HSA-9818027] NFE2L2 regulating anti-oxidant/detoxification enzymes
(precedingEvent)	[BlackBoxEvent:R-HSA-9760128] AcK-NFE2L2-dependent GSTA1 gene expression