AcK-NFE2L2 and MAFK bind the GSTA1 gene

Stable Identifier
R-HSA-9760097
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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AcK-NFE2L2 and MAFK bind the GSTA1 gene
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Phosphorylated, acetylated NFE2L2 binds to the antioxidant response element (ARE) in the promoter of the GSTA1 gene as assessed by electrophoretic mobility shift assay in mouse and stimulates GSTA1 expression (Itoh et al, 1997; Thimmulappa et al, 2002; Sun et al, 2009). GSTA1 protein expressed downstream of the KEAP1:NFE2L2 pathway contributes to the antioxidant response by catalyzing the nucleophilic attack of glutathione on endogenous and exogenous electrophilic compounds (reviewed in Baird and Yamamoto, 2020; Chatterjee et al, 2018).
Literature References
PubMed ID Title Journal Year
12234984 Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray

Yamamoto, M, Srisuma, S, Mai, KH, Biswal, S, Thimmulappa, RK, Kensler, TW

Cancer Res 2002
9240432 An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

Ishii, T, Hatayama, I, Nabeshima, Y, Yamamoto, M, Takahashi, S, Satoh, K, Oyake, T, Hayashi, N, Igarashi, K, Itoh, K, Chiba, T, Katoh, Y

Biochem Biophys Res Commun 1997
32284348 The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

Yamamoto, M, Baird, L

Mol Cell Biol 2020
29959055 The multifaceted role of glutathione S-transferases in cancer

Chatterjee, A, Gupta, S

Cancer Lett 2018
19273602 Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response

Sun, Z, Zhang, DD, Chin, YE

Mol Cell Biol 2009
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Authored
Rothfels, K  (2021-10-08)
Reviewed
Cuadrado, A  (2022-02-23)
Created
Rothfels, K  (2021-12-14)
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