Reactome | NFE2L2-dependent GSTA3 gene expression

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NFE2L2-dependent GSTA3 gene expression Show undefined attributes

authored	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9759360] Rothfels, Karen, 2021-12-02
dbId	9759356
displayName	NFE2L2-dependent GSTA3 gene expression
edited	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
eventOf	[Pathway:R-HSA-9818027] NFE2L2 regulating anti-oxidant/detoxification enzymes - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9759330] GSTA3 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9758970] An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements [LiteratureReference:9759034] The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes [LiteratureReference:9759274] Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis [LiteratureReference:9708494] The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NFE2L2-dependent GSTA3 gene expression
output	[Complex:R-HSA-3301921] GSTA3 dimer [cytosol]
precedingEvent	[Reaction:R-HSA-9759325] NFE2L2 binds the GSTA3 promoter - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:9759359] Positive gene expression regulation by 'GSTA3 gene:p-NFE2L2 [nucleoplasm]'
regulationReference	[RegulationReference:9759357] Positive gene expression regulation by 'GSTA3 gene:p-NFE2L2 [nucleoplasm]' Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis
releaseDate	2022-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9759356
summation	[Summation:9759312] GSTA3 is a glutathione-S-transferase that conjugates reduced...

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(hasEvent)

[Pathway:R-HSA-9818027] NFE2L2 regulating anti-oxidant/detoxification enzymes