NFE2L2-dependent GSTA3 gene expression

Stable Identifier
R-HSA-9759356
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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NFE2L2-dependent GSTA3 gene expression
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GSTA3 is a glutathione-S-transferase that conjugates reduced glutathione to hydrophobic electrophiles. GSTA3 expression is regulated by the KEAP1-NFE2L2 pathway (Itoh et al, 1997; McMahon et al, 2001; Malhotra et al, 2010; reviewed in Baird and Yamamoto, 2020).
Literature References
PubMed ID Title Journal Year
20460467 Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

Shyr, C, Srivastava, S, Wakabayashi, N, Wasserman, WW, Singh, A, Malhotra, D, Biswal, S, Happel, C, Portales-Casamar, E, Kensler, TW, Arenillas, D

Nucleic Acids Res 2010
11309284 The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes

Cavin, C, Wolf, CR, Chanas, SA, McMahon, M, McLellan, LI, Henderson, CJ, Yamamoto, M, Hayes, JD, Itoh, K

Cancer Res 2001
9240432 An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

Ishii, T, Hatayama, I, Nabeshima, Y, Yamamoto, M, Takahashi, S, Satoh, K, Oyake, T, Hayashi, N, Igarashi, K, Itoh, K, Chiba, T, Katoh, Y

Biochem Biophys Res Commun 1997
32284348 The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

Yamamoto, M, Baird, L

Mol Cell Biol 2020
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
GSTA3 gene:p-NFE2L2 [nucleoplasm] (Homo sapiens)
Active Unit
p-NFE2L2 [nucleoplasm]
Authored
Rothfels, K  (2021-10-08)
Reviewed
Cuadrado, A  (2022-02-23)
Created
Rothfels, K  (2021-12-02)
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