Reactome | Addition of a GlcNAc on the alpha 1,4 branch by MGAT2

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Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 Show undefined attributes

authored	[InstanceEdit:749521] Dall'Olio, GM, 2009-11-10
catalystActivity	[CatalystActivity:975825] alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity of MGAT2 [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:975827] Jassal, B, 2010-10-04
dbId	975829
diseaseReaction	[FailedReaction:R-HSA-4793955] Defective MGAT2 does not transfer GlcNAc to N-glycans - Homo sapiens
displayName	Addition of a GlcNAc on the alpha 1,4 branch by MGAT2
edited	[InstanceEdit:975827] Jassal, B, 2010-10-04
eventOf	[Pathway:R-HSA-975578] Reactions specific to the complex N-glycan synthesis pathway - Homo sapiens
input	[SimpleEntity:R-ALL-975819] (GlcNAc)3 (Man)3 (Asn)1 [Golgi lumen] [SimpleEntity:R-ALL-914003] UDP-GlcNAc [Golgi lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1015715] Mutations in the MGAT2 gene controlling complex N-glycan synthesis cause carbohydrate-deficient glycoprotein syndrome type II, an autosomal recessive disease with defective brain development [LiteratureReference:1015735] The human UDP-N-acetylglucosamine: alpha-6-D-mannoside-beta-1,2- N-acetylglucosaminyltransferase II gene (MGAT2). Cloning of genomic DNA, localization to chromosome 14q21, expression in insect cells and purification of the recombinant protein [LiteratureReference:1015729] Mice with a homozygous deletion of the Mgat2 gene encoding UDP-N-acetylglucosamine:alpha-6-D-mannoside beta1,2-N-acetylglucosaminyltransferase II: a model for congenital disorder of glycosylation type IIa
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Addition of a GlcNAc on the alpha 1,4 branch by MGAT2
orthologousEvent	[Reaction:R-BTA-975829] Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 - Bos taurus [Reaction:R-CEL-975829] Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 - Caenorhabditis elegans [Reaction:R-DME-975829] Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 - Drosophila melanogaster [Reaction:R-GGA-975829] Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 - Gallus gallus [Reaction:R-XTR-975829] Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 - Xenopus tropicalis [Reaction:R-DRE-975829] Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 - Danio rerio [Reaction:R-SSC-975829] Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 - Sus scrofa [Reaction:R-CFA-975829] Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 - Canis familiaris [Reaction:R-RNO-975829] Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 - Rattus norvegicus [Reaction:R-MMU-975829] Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 - Mus musculus
output	[SimpleEntity:R-ALL-975822] (GlcNAc)4 (Man)3 (Asn)1 [Golgi lumen] [SimpleEntity:R-ALL-205687] UDP [Golgi lumen]
precedingEvent	[Reaction:R-HSA-975814] Trimming of mannoses on the alpha1,6 arm by MAN2A1 - Homo sapiens
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1028799] Gagneux, P, 2010-11-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-975829
summation	[Summation:1015746] The addition of a GlcNAc on the alpha-1,6 mannose on the alp...
updateTrackers	[UpdateTracker:9781943] Update Tracker - [Reaction:975829] Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 - v60:[addOutput] [UpdateTracker:9785923] Update Tracker - [Reaction:975829] Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 - v51:[modifyText] [UpdateTracker:9786893] Update Tracker - [Reaction:975829] Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 - v47:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9781943] Update Tracker - [Reaction:975829] Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 - v60:[addOutput] [UpdateTracker:9785923] Update Tracker - [Reaction:975829] Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 - v51:[modifyText] [UpdateTracker:9786893] Update Tracker - [Reaction:975829] Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 - v47:[modifyText]
(normalReaction)	[FailedReaction:R-HSA-4793955] Defective MGAT2 does not transfer GlcNAc to N-glycans
(hasEvent)	[Pathway:R-HSA-975578] Reactions specific to the complex N-glycan synthesis pathway

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