Addition of a GlcNAc on the alpha 1,4 branch by MGAT2

Stable Identifier
R-HSA-975829
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi membrane, Golgi lumen
ReviewStatus
5/5
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Addition of a GlcNAc on the alpha 1,4 branch by MGAT2
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The addition of a GlcNAc on the alpha-1,6 mannose on the alpha-1,4 branch is required for the synthesis of complex N-glycans (Tan et al. 1995). Defects in this gene are associated with Congenital Disorder of Glycosylation type IIa (Tan et al. 1996, Wang et al. 2002).
Literature References
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as an event of
Catalyst Activity

alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity of MGAT2 [Golgi membrane]

Physical Entity
MGAT2 [Golgi membrane] (Homo sapiens)
Activity
alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity (GO:0008455)
Orthologous Events
Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Bos taurus)
Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Caenorhabditis elegans)
Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Canis familiaris)
Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Danio rerio)
Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Drosophila melanogaster)
Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Gallus gallus)
Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Mus musculus)
Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Rattus norvegicus)
Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Sus scrofa)
Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Xenopus tropicalis)
Authored
Dall'Olio, GM  (2009-11-10)
Reviewed
Gagneux, P  (2010-11-18)
Created
Jassal, B  (2010-10-04)
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