The addition of a GlcNAc on the alpha-1,6 mannose on the alpha-1,4 branch is required for the synthesis of complex N-glycans (Tan et al. 1995). Defects in this gene are associated with Congenital Disorder of Glycosylation type IIa (Tan et al. 1996, Wang et al. 2002).
Tan, J, Dunn, J, Jaeken, J, Schachter, H
Wang, Y, Schachter, H, Marth, JD
Tan, J, D'Agostaro, AF, Bendiak, B, Reck, F, Sarkar, M, Squire, JA, Leong, P, Schachter, H
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