Reactome | CYP3A4 monooxygenates ATVL to 4-OH-ATVL

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CYP3A4 monooxygenates ATVL to 4-OH-ATVL Show undefined attributes

authored	[InstanceEdit:9756176] Jassal, Bijay, 2021-10-12
catalystActivity	[CatalystActivity:9756317] monooxygenase activity of CYP3A4 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:9756176] Jassal, Bijay, 2021-10-12
dbId	9756180
displayName	CYP3A4 monooxygenates ATVL to 4-OH-ATVL
edited	[InstanceEdit:9756176] Jassal, Bijay, 2021-10-12
eventOf	[Pathway:R-HSA-9754706] Atorvastatin ADME - Homo sapiens
followingEvent	[Reaction:R-HSA-9756150] PON1,3 hydrolyse 4-OH-ATVL to 4-OH-ATV - Homo sapiens
input	[ChemicalDrug:R-ALL-9756319] ATVL [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9756801] Contribution of cytochrome P450 3A4 and 3A5 to the metabolism of atorvastatin [LiteratureReference:9756797] Comparative Hepatic and Intestinal Metabolism and Pharmacodynamics of Statins [LiteratureReference:9756164] Lactonization is the critical first step in the disposition of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin [LiteratureReference:9756790] Metabolic properties of the acid and lactone forms of HMG-CoA reductase inhibitors
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	CYP3A4 monooxygenates ATVL to 4-OH-ATVL
orthologousEvent	[Reaction:R-GGA-9756180] CYP3A4 monooxygenates ATVL to 4-OH-ATVL - Gallus gallus [Reaction:R-XTR-9756180] CYP3A4 monooxygenates ATVL to 4-OH-ATVL - Xenopus tropicalis [Reaction:R-DRE-9756180] CYP3A4 monooxygenates ATVL to 4-OH-ATVL - Danio rerio [Reaction:R-SSC-9756180] CYP3A4 monooxygenates ATVL to 4-OH-ATVL - Sus scrofa [Reaction:R-BTA-9756180] CYP3A4 monooxygenates ATVL to 4-OH-ATVL - Bos taurus [Reaction:R-CFA-9756180] CYP3A4 monooxygenates ATVL to 4-OH-ATVL - Canis familiaris [Reaction:R-RNO-9756180] CYP3A4 monooxygenates ATVL to 4-OH-ATVL - Rattus norvegicus [Reaction:R-MMU-9756180] CYP3A4 monooxygenates ATVL to 4-OH-ATVL - Mus musculus
output	[SimpleEntity:R-ALL-9756326] 4-OH-ATVL [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9756156] UGT1A3 lactonizes ATV to ATVL - Homo sapiens
releaseDate	2022-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9767610] Huddart, Rachel, 2022-03-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9756180
summation	[Summation:9756803] Atorvastatin lactone (ATVL) is hydroxylated to hydroxy-metab...

Referrals

(precedingEvent)	[Reaction:R-HSA-9756150] PON1,3 hydrolyse 4-OH-ATVL to 4-OH-ATV
(hasEvent)	[Pathway:R-HSA-9754706] Atorvastatin ADME