Reactome | CYP3A4 monooxygenates ATVL to 4-OH-ATVL

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CYP3A4 monooxygenates ATVL to 4-OH-ATVL Show undefined attributes

catalystActivity	[CatalystActivity:10288556] monooxygenase activity of CYP1A2,3A4 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10322246
displayName	CYP3A4 monooxygenates ATVL to 4-OH-ATVL
eventOf	[Pathway:R-CFA-9754706] Atorvastatin ADME - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9756180] CYP3A4 monooxygenates ATVL to 4-OH-ATVL - Homo sapiens
input	[ChemicalDrug:R-ALL-9756319] ATVL [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CYP3A4 monooxygenates ATVL to 4-OH-ATVL
output	[SimpleEntity:R-ALL-9756326] 4-OH-ATVL [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-9756180
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-9754706] Atorvastatin ADME
(inferredTo)	[Reaction:R-HSA-9756180] CYP3A4 monooxygenates ATVL to 4-OH-ATVL

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