Reactome | MUL1 ubiquitinates UBXN7

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MUL1 ubiquitinates UBXN7 Show undefined attributes

authored	[InstanceEdit:9766710] Rothfels, Karen, 2022-02-23
catalystActivity	[CatalystActivity:9755302] ubiquitin protein ligase activity of MUL1 dimer [mitochondrial outer membrane]
category	transition
compartment	[Compartment:17906] mitochondrial outer membrane [Compartment:70101] cytosol
created	[InstanceEdit:9755309] Rothfels, Karen, 2021-10-07
dbId	9755304
displayName	MUL1 ubiquitinates UBXN7
edited	[InstanceEdit:9766710] Rothfels, Karen, 2022-02-23
eventOf	[Pathway:R-HSA-9755511] KEAP1-NFE2L2 pathway - Homo sapiens [Pathway:R-HSA-8951664] Neddylation - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9755306] ub UBXN7 is degraded by the 26S proteasome - Homo sapiens
input	3 × [DefinedSet:R-HSA-113595] Ub [cytosol] [EntityWithAccessionedSequence:R-HSA-8956071] UBXN7 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9755287] UBXN7 cofactor of CRL3^KEAP1 and CRL2^VHL ubiquitin ligase complexes mediates reciprocal regulation of NRF2 and HIF-1? proteins [LiteratureReference:9755296] Mitochondrial MUL1 E3 ubiquitin ligase regulates Hypoxia Inducible Factor (HIF-1?) and metabolic reprogramming by modulating the UBXN7 cofactor protein [LiteratureReference:392077] Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex [LiteratureReference:1233950] Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex [LiteratureReference:392095] Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein [LiteratureReference:1233955] Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein [LiteratureReference:1234031] Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex [LiteratureReference:8932344] Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain [LiteratureReference:8932282] The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase [LiteratureReference:8932330] Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2 [LiteratureReference:8932359] Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex [LiteratureReference:8932346] BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase [LiteratureReference:9755478] p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 Complex
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	MUL1 ubiquitinates UBXN7
orthologousEvent	[Reaction:R-MMU-9755304] MUL1 ubiquitinates UBXN7 - Mus musculus [Reaction:R-DME-9755304] MUL1 ubiquitinates UBXN7 - Drosophila melanogaster [Reaction:R-GGA-9755304] MUL1 ubiquitinates UBXN7 - Gallus gallus [Reaction:R-DRE-9755304] MUL1 ubiquitinates UBXN7 - Danio rerio [Reaction:R-SSC-9755304] MUL1 ubiquitinates UBXN7 - Sus scrofa [Reaction:R-BTA-9755304] MUL1 ubiquitinates UBXN7 - Bos taurus [Reaction:R-RNO-9755304] MUL1 ubiquitinates UBXN7 - Rattus norvegicus
output	[EntityWithAccessionedSequence:R-HSA-9755305] ub-UBXN7 [cytosol]
releaseDate	2022-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9755304
summation	[Summation:9758073] MUL1 is an E3 ligase located in the outer mitochondrial memb...

Referrals

(hasEvent)	[Pathway:R-HSA-8951664] Neddylation [Pathway:R-HSA-9755511] KEAP1-NFE2L2 pathway
(precedingEvent)	[BlackBoxEvent:R-HSA-9755306] ub UBXN7 is degraded by the 26S proteasome

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