Reactome | SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix

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SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix Show undefined attributes

authored	[InstanceEdit:9755068] Stephan, Ralf, 2021-09-20
catalystActivity	[CatalystActivity:9754975] nucleoside transmembrane transporter activity of SLC29A3 [mitochondrial outer membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:5460] mitochondrial matrix [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:9755067] Stephan, Ralf, 2021-10-05
dbId	9754929
displayName	SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix
edited	[InstanceEdit:9767894] Stephan, Ralf, 2022-03-02
eventOf	[Pathway:R-HSA-9755088] Ribavirin ADME - Homo sapiens
input	[DefinedSet:R-ALL-9754954] RBV,RBV-TP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9755034] Facilitated mitochondrial import of antiviral and anticancer nucleoside drugs by human equilibrative nucleoside transporter-3 [LiteratureReference:9755049] Electrophysiological characterization and modeling of the structure activity relationship of the human concentrative nucleoside transporter 3 (hCNT3) [LiteratureReference:9761929] Mitochondrial toxicity is associated with virological response in patients with HIV and hepatitis C virus coinfection treated with ribavirin and highly active antiretroviral therapy
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix SLC29A3 imports RBV,RBV-TP to mitochondria
orthologousEvent	[Reaction:R-PFA-9754929] SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix - Plasmodium falciparum [Reaction:R-SCE-9754929] SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix - Saccharomyces cerevisiae [Reaction:R-DDI-9754929] SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix - Dictyostelium discoideum [Reaction:R-CEL-9754929] SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix - Caenorhabditis elegans [Reaction:R-DME-9754929] SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix - Drosophila melanogaster [Reaction:R-GGA-9754929] SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix - Gallus gallus [Reaction:R-SSC-9754929] SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix - Sus scrofa [Reaction:R-BTA-9754929] SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix - Bos taurus [Reaction:R-CFA-9754929] SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix - Canis familiaris [Reaction:R-RNO-9754929] SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix - Rattus norvegicus [Reaction:R-MMU-9754929] SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix - Mus musculus
output	[DefinedSet:R-ALL-9754996] RBV,RBV-TP [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-9754934] SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-9755015] SLC29A1 transports RBV from extracellular region to cytosol - Homo sapiens [BlackBoxEvent:R-HSA-9755078] NT5C2 tetramer dephosphorylates RBV-MP - Homo sapiens [Reaction:R-HSA-9755013] NME1,2 hexamers phosphorylate RBV-DP - Homo sapiens
releaseDate	2022-09-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9793976] Thorn, Caroline, 2022-06-25
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9754929
summation	[Summation:9755001] Equilibrative nucleoside transporter 3 (ENT3, SLC29A3) is an...

Referrals

(hasEvent)

[Pathway:R-HSA-9755088] Ribavirin ADME