Reactome | SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix

SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix

Stable Identifier

R-HSA-9754929

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, mitochondrial matrix, mitochondrial outer membrane

Synonyms

SLC29A3 imports RBV,RBV-TP to mitochondria

ReviewStatus

5/5

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SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix

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Equilibrative nucleoside transporter 3 (ENT3, SLC29A3) is an intracellular transporter involved in mitochondrial import of ribavirin (RBV) and RBV-TP (Hu et al, 2006; Govindarajan et al, 2009). Mitochondrial import of RBV appears to be a factor contributing to mitochondrial toxicity in patients treated with both RBV and highly active antiretrovirals (HAART) (Reiberger et al, 2010).

Literature References

PubMed ID	Title	Journal	Year
19164483	Facilitated mitochondrial import of antiviral and anticancer nucleoside drugs by human equilibrative nucleoside transporter-3 Govindarajan, R, Leung, GP, Zhou, M, Tse, CM, Wang, J, Unadkat, JD	Am J Physiol Gastrointest Liver Physiol	2009
20486858	Mitochondrial toxicity is associated with virological response in patients with HIV and hepatitis C virus coinfection treated with ribavirin and highly active antiretroviral therapy Reiberger, T, Kosi, L, Maresch, J, Breitenecker, F, Payer, BA, Wrba, F, Rieger, A, Gangl, A, Peck-Radosavljevic, M	J Infect Dis	2010
16446384	Electrophysiological characterization and modeling of the structure activity relationship of the human concentrative nucleoside transporter 3 (hCNT3) Hu, H, Endres, CJ, Chang, C, Umapathy, NS, Lee, EW, Fei, YJ, Itagaki, S, Swaan, PW, Ganapathy, V, Unadkat, JD	Mol Pharmacol	2006