Reactome | CDT1-mediated formation of MCM2-7 double hexamer at the replication origin

Schema > Reaction > Entries

authored	[InstanceEdit:9757622] Kusic-Tisma, Jelena, 2021-10-27
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9749352] Orlic-Milacic, Marija, 2021-08-01
dbId	9749351
deleted	[Deleted:9768313] Deletion of instance: 68827
displayName	CDT1-mediated formation of MCM2-7 double hexamer at the replication origin
edited	[InstanceEdit:9757621] Orlic-Milacic, Marija, 2021-11-03
eventOf	[Pathway:R-HSA-68867] Assembly of the pre-replicative complex - Homo sapiens
inferredFrom	[Reaction:R-SCE-9749401] CTD1-mediated formation of MCM2-7 double hexamers at the replication origins in budding yeast - Saccharomyces cerevisiae
input	[Complex:R-HSA-9749283] CDT1:MCM2-7 [nucleoplasm] [Complex:R-HSA-9749356] ORC(1-6):CDC6:origin of replication:MCM2-7 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CDT1-mediated formation of MCM2-7 double hexamer at the replication origin
output	[EntityWithAccessionedSequence:R-HSA-68536] CDT1 [nucleoplasm] [Complex:R-HSA-9749359] ORC(1-6):CDC6:origin or replication:MCM2-7 double hexamer [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9749350] ATP-dependent release of CDT1 from the OCCM complex - Homo sapiens
releaseDate	2021-12-08
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9749351
summation	[Summation:9749398] Based on studies in budding yeast, after CDT1-mediated loadi...

(replacementInstances)	[Deleted:9768313] Deletion of instance: 68827
(hasEvent)	[Pathway:R-HSA-68867] Assembly of the pre-replicative complex
(inferredTo)	[Reaction:R-SCE-9749401] CTD1-mediated formation of MCM2-7 double hexamers at the replication origins in budding yeast

Cite Us!