Reactome | TP53 R342P [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

TP53 R342P [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9726100] Orlic-Milacic, Marija, 2021-04-05
crossReference	[DatabaseIdentifier:12021425] Mondo:0002447 [DatabaseIdentifier:9726099] COSMIC:COSV52690857
dbId	9726101
disease	[Disease:1500689] cancer [Disease:9660681] adrenocortical carcinoma [Disease:9659088] osteosarcoma [Disease:1500576] breast cancer [Disease:9669011] breast ductal carcinoma [Disease:1996318] astrocytoma [Disease:9662153] colon adenocarcinoma [Disease:2317358] endometrial cancer [Disease:9701263] endometrial carcinoma [Disease:9631014] renal Wilms' tumor [Disease:9648692] brain ependymoma [Disease:9660678] liver carcinoma [Disease:8853117] lung adenocarcinoma [Disease:1500575] ovarian cancer [Disease:1655494] prostate adenocarcinoma [Disease:9701260] salivary gland carcinoma [Disease:9660682] thyroid gland anaplastic carcinoma
displayName	TP53 R342P [nucleoplasm]
endCoordinate	393
hasModifiedResidue	[ReplacedResidue:9726105] L-arginine 342 replaced with L-proline
inDisease	true
literatureReference	[LiteratureReference:9726103] p53 mutants without a functional tetramerisation domain are not oncogenic [LiteratureReference:9726293] Characterization of p53 mutants identified in human tumors with a missense mutation in the tetramerization domain [LiteratureReference:9726313] Cancer-associated p53 tetramerization domain mutants: quantitative analysis reveals a low threshold for tumor suppressor inactivation
maxDepth	1
memberOf	[CandidateSet:R-HSA-9720037] TP53 mutants (tetramerization) [nucleoplasm] - Homo sapiens
modified	[InstanceEdit:9730928] Matthews, Lisa, 2021-05-12
name	TP53 R342P
referenceEntity	[ReferenceGeneProduct:uniprot:P04637] UniProt:P04637 TP53
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9726101
startCoordinate	1

Referrals

(hasMember)

[CandidateSet:R-HSA-9720037] TP53 mutants (tetramerization) [nucleoplasm]