Reactome | p-Y ALK S1206C [plasma membrane]

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p-Y ALK S1206C [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9715329] p-Y ALK S1206C dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9715329] p-Y ALK S1206C dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9715288] Rothfels, Karen, 2021-02-17
crossReference	[DatabaseIdentifier:12020794] Mondo:0005233 [DatabaseIdentifier:9715229] COSMIC:COSM9311656
dbId	9715292
disease	[Disease:1247848] non-small cell lung carcinoma
displayName	p-Y ALK S1206C [plasma membrane]
endCoordinate	1620
hasModifiedResidue	[ReplacedResidue:9715215] L-serine 1206 replaced with L-cysteine [ModifiedResidue:9699796] O4'-phospho-L-tyrosine at 1096 [ModifiedResidue:9699868] O4'-phospho-L-tyrosine at 1278 [ModifiedResidue:9699844] O4'-phospho-L-tyrosine at 1282 [ModifiedResidue:9699911] O4'-phospho-L-tyrosine at 1283 [ModifiedResidue:9699876] O4'-phospho-L-tyrosine at 1359 [ModifiedResidue:9699886] O4'-phospho-L-tyrosine at 1507 [ModifiedResidue:9699803] O4'-phospho-L-tyrosine at 1604
inDisease	true
literatureReference	[LiteratureReference:9713917] Molecular Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in ALK-Rearranged Lung Cancer [LiteratureReference:9700357] Treatment Efficacy and Resistance Mechanisms Using the Second-Generation ALK Inhibitor AP26113 in Human NPM-ALK-Positive Anaplastic Large Cell Lymphoma
maxDepth	1
name	p-Y ALK S1206C ALK tyrosine kinase receptor ALK_HUMAN
referenceEntity	[ReferenceGeneProduct:uniprot:Q9UM73] UniProt:Q9UM73 ALK
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9715292
startCoordinate	19

Referrals

(hasComponent)

[Complex:R-HSA-9715329] p-Y ALK S1206C dimer [plasma membrane]

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