Reactome | ALK S1206C [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9715310] ALK S1206C dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9715310] ALK S1206C dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9715264] Rothfels, Karen, 2021-02-17
crossReference	[DatabaseIdentifier:12020794] Mondo:0005233 [DatabaseIdentifier:9715229] COSMIC:COSM9311656
dbId	9715268
disease	[Disease:1247848] non-small cell lung carcinoma
displayName	ALK S1206C [plasma membrane]
endCoordinate	1620
hasModifiedResidue	[ReplacedResidue:9715215] L-serine 1206 replaced with L-cysteine
inDisease	true
literatureReference	[LiteratureReference:9713917] Molecular Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in ALK-Rearranged Lung Cancer [LiteratureReference:9700357] Treatment Efficacy and Resistance Mechanisms Using the Second-Generation ALK Inhibitor AP26113 in Human NPM-ALK-Positive Anaplastic Large Cell Lymphoma
maxDepth	1
memberOf	[CandidateSet:R-HSA-9700083] kinase domain ALK mutants [plasma membrane] - Homo sapiens
name	ALK S1206C ALK tyrosine kinase receptor ALK_HUMAN
referenceEntity	[ReferenceGeneProduct:uniprot:Q9UM73] UniProt:Q9UM73 ALK
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9715268
startCoordinate	19

(hasMember)	[CandidateSet:R-HSA-9700083] kinase domain ALK mutants [plasma membrane]
(hasComponent)	[Complex:R-HSA-9715310] ALK S1206C dimer [plasma membrane]

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