Reactome | IRS- and FRS-binding ALK fusion proteins [cytosol]

Schema > CandidateSet > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9712076] p-Y IRS1:ALK fusion proteins [cytosol] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9712088] ALK fusion proteins bind IRS - Homo sapiens [Reaction:R-HSA-9712081] ALK fusions bind FRS - Homo sapiens
created	[InstanceEdit:9713535] Rothfels, Karen, 2021-01-26
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9713536
deleted	[Deleted:9751189] Deletion of instance: 9713533
disease	[Disease:1500689] cancer
displayName	IRS- and FRS-binding ALK fusion proteins [cytosol]
hasCandidate	[Complex:R-HSA-9730706] NPM1(1-117)-p-7Y ALK(1068-1620) fusion dimer [cytosol] - Homo sapiens
hasMember	[Complex:R-HSA-9699991] NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:9699737] Nucleophosmin-anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling pathway [LiteratureReference:9730688] Molecular detection of the (2;5) translocation of non-Hodgkin's lymphoma by reverse transcriptase-polymerase chain reaction
maxDepth	3
modified	[InstanceEdit:9751186] Rothfels, Karen, 2021-08-19
name	IRS- and FRS-binding ALK fusion proteins
schemaClass	CandidateSet
species	[Species:48887] Homo sapiens
stId	R-HSA-9713536
updateTrackers	[UpdateTracker:9902668] Update Tracker - [CandidateSet:9713536] IRS- and FRS-binding ALK fusion proteins [cytosol] - v78:[modifyName]

(updatedInstance)	[UpdateTracker:9902668] Update Tracker - [CandidateSet:9713536] IRS- and FRS-binding ALK fusion proteins [cytosol] - v78:[modifyName]
(replacementInstances)	[Deleted:9751189] Deletion of instance: 9713533
(input)	[Reaction:R-HSA-9712088] ALK fusion proteins bind IRS [Reaction:R-HSA-9712081] ALK fusions bind FRS
(hasComponent)	[Complex:R-HSA-9712076] p-Y IRS1:ALK fusion proteins [cytosol] [Complex:R-HSA-9711940] IRS:ALK fusion proteins [cytosol] [Complex:R-HSA-9712069] ALK fusions:p-6Y FRS [cytosol] [Complex:R-HSA-9711938] ALK fusions:FRS [cytosol]

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