Reactome | HIP1(1-1019)-p-7Y-ALK(1058-1620) [cytosol]

Schema > EntityWithAccessionedSequence > Entries

HIP1(1-1019)-p-7Y-ALK(1058-1620) [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9712024] HIP1(1-1019)-p-7Y ALK(1058-1620) dimer [cytosol] - Homo sapiens [Complex:R-HSA-9712024] HIP1(1-1019)-p-7Y ALK(1058-1620) dimer [cytosol] - Homo sapiens
created	[InstanceEdit:9711957] Rothfels, Karen, 2021-01-13
crossReference	[DatabaseIdentifier:12020833] Mondo:0005061 [DatabaseIdentifier:9711758] COSMIC:COSF1712
dbId	9711956
disease	[Disease:8853117] lung adenocarcinoma
displayName	HIP1(1-1019)-p-7Y-ALK(1058-1620) [cytosol]
endCoordinate	1019
hasModifiedResidue	[FragmentInsertionModification:9711914] Insertion of residues 1058 to 1620 at 1020 from UniProt:Q9UM73 ALK [ModifiedResidue:9699796] O4'-phospho-L-tyrosine at 1096 [ModifiedResidue:9699868] O4'-phospho-L-tyrosine at 1278 [ModifiedResidue:9699844] O4'-phospho-L-tyrosine at 1282 [ModifiedResidue:9699911] O4'-phospho-L-tyrosine at 1283 [ModifiedResidue:9699876] O4'-phospho-L-tyrosine at 1359 [ModifiedResidue:9699886] O4'-phospho-L-tyrosine at 1507 [ModifiedResidue:9699803] O4'-phospho-L-tyrosine at 1604
inDisease	true
literatureReference	[LiteratureReference:9711845] Identification of a novel HIP1-ALK fusion variant in Non-Small-Cell Lung Cancer (NSCLC) and discovery of ALK I1171 (I1171N/S) mutations in two ALK-rearranged NSCLC patients with resistance to Alectinib
maxDepth	1
modified	[InstanceEdit:9832318] Orlic-Milacic, Marija, 2023-03-30
name	HIP1(1-1019)-p-7Y-ALK(1058-1620) Huntingtin-interacting protein 1 HIP1_HUMAN
referenceEntity	[ReferenceGeneProduct:uniprot:O00291] UniProt:O00291 HIP1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9711956
startCoordinate	1
updateTrackers	[UpdateTracker:9905217] Update Tracker - [EntityWithAccessionedSequence:9711956] HIP1(1-1019)-p-7Y-ALK(1058-1620) [cytosol] - v85:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9905217] Update Tracker - [EntityWithAccessionedSequence:9711956] HIP1(1-1019)-p-7Y-ALK(1058-1620) [cytosol] - v85:[modifyName]
(hasComponent)	[Complex:R-HSA-9712024] HIP1(1-1019)-p-7Y ALK(1058-1620) dimer [cytosol]

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