Reactome | PI3K-binding ALK mutants [cytosol]

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PI3K-binding ALK mutants [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9711928] ALK mutants:PIK3R1 [cytosol] - Homo sapiens
consumedByEvent	[BlackBoxEvent:R-HSA-9712078] ALK mutants bind PI3KR1 - Homo sapiens
created	[InstanceEdit:9711927] Rothfels, Karen, 2021-01-13
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9711929
disease	[Disease:1500689] cancer
displayName	PI3K-binding ALK mutants [cytosol]
hasCandidate	[Complex:R-HSA-9710879] CLTC(2-1634)-p-7Y ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9712037] DCTN1(1-1177)-p-7Y ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9712034] DCTN1(1-599)-p-7Y ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9716118] EML4(1-780)-p-7Y ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens
hasMember	[Complex:R-HSA-9699991] NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9710884] CLTC(2-1634)-p-7Y ALK(1059-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9712018] DCTN1(1-1065)-p-7Y ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9700018] EML4(1-223)-p-7Y ALK(1059-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9699994] EML4(1-223)insKMSTREKNSQV -p-7Y ALK(1059-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9700010] EML4(1-486)-p-7Y ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9716117] EML4(1-569)-p-7Y ALK(1078-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9711939] KIF5B(2-575)-p-7Y ALK(1063-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9713501] FN1(32-1201)-p-7Y ALK(1022-1620) fusion dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9699988] p-7Y ALK F1174I dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9700020] p-7Y ALK F1174L dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9700016] p-7Y ALK F1174S dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9699979] p-7Y ALK R1275Q dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9700554] p-7Y ALK K1062M dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9723883] p-7Y ALK del224-318 dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9723886] p-7Y ALK del318-782 dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9701888] p-7Y ALK L1198F dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9701866] p-7Y ALK G1201E dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9700563] p-7Y ALK G1128A dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9700532] p-7Y ALK I1171N dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9700612] p-7Y ALK R1192P dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9700603] p-7Y ALK F1245C dimer [plasma membrane] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:9699737] Nucleophosmin-anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling pathway [LiteratureReference:9710767] Inhibition of anaplastic lymphoma kinase (ALK) activity provides a therapeutic approach for CLTC-ALK-positive human diffuse large B cell lymphomas [LiteratureReference:9711768] Kinase fusions are frequent in Spitz tumours and spitzoid melanomas [LiteratureReference:9716071] EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer [LiteratureReference:9701376] Role of ERK-BIM and STAT3-survivin signaling pathways in ALK inhibitor-induced apoptosis in EML4-ALK-positive lung cancer [LiteratureReference:9711805] A novel KIF5B-ALK variant in nonsmall cell lung cancer [LiteratureReference:9713378] Identification of anaplastic lymphoma kinase as a potential therapeutic target in ovarian cancer [LiteratureReference:9700372] Oncogenic mutations of ALK kinase in neuroblastoma [LiteratureReference:9723288] Cell culture and Drosophila model systems define three classes of anaplastic lymphoma kinase mutations in neuroblastoma [LiteratureReference:9700412] Activating mutations in ALK provide a therapeutic target in neuroblastoma [LiteratureReference:9723851] Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma [LiteratureReference:9723810] Aberrant activation of ALK kinase by a novel truncated form ALK protein in neuroblastoma [LiteratureReference:9723824] Characterization of rearrangements involving the ALK gene reveals a novel truncated form associated with tumor aggressiveness in neuroblastoma [LiteratureReference:9701769] Anaplastic thyroid cancers harbor novel oncogenic mutations of the ALK gene [LiteratureReference:9723817] Activating ALK mutations found in neuroblastoma are inhibited by Crizotinib and NVP-TAE684
maxDepth	3
modified	[InstanceEdit:9729687] Rothfels, Karen, 2021-05-03
name	PI3K-binding ALK mutants
schemaClass	CandidateSet
species	[Species:48887] Homo sapiens
stId	R-HSA-9711929

Referrals

(hasComponent)	[Complex:R-HSA-9711928] ALK mutants:PIK3R1 [cytosol]
(input)	[BlackBoxEvent:R-HSA-9712078] ALK mutants bind PI3KR1
(activeUnit)	[CatalystActivity:9711936] protein tyrosine kinase activity of IRS:ALK fusion proteins [cytosol] [CatalystActivity:9711941] protein tyrosine kinase activity of ALK fusions:FRS [cytosol] [CatalystActivity:9711930] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of PI3K-binding ALK fusions:PI3K [cytosol]

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