Reactome | IRF2 or IRF1 binds the GSDMD gene promoter

Schema > Reaction > Entries

authored	[InstanceEdit:9706708] Shamovsky, Veronica, 2020-11-09
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9710288] Shamovsky, Veronica, 2020-12-28
dbId	9710295
displayName	IRF2 or IRF1 binds the GSDMD gene promoter
edited	[InstanceEdit:9715950] Shorser, Solomon, 2021-02-17
eventOf	[Pathway:R-HSA-5620971] Pyroptosis - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9710294] GSDMD expression mediated by IRF2, IRF1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-8963121] GSDMD gene [nucleoplasm] [CandidateSet:R-HSA-9710298] IRF2, IRF1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9710293] IRF2 transcriptionally induces GSDMD expression for pyroptosis
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IRF2 or IRF1 binds the GSDMD gene promoter
output	[Complex:R-HSA-9710284] IRF2, IRF1:GSDMD gene [nucleoplasm]
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9715448] Kanneganti, Thirumala-Devi, 2021-02-17 [InstanceEdit:9715449] D'Eustachio, Peter, 2021-02-17 [InstanceEdit:9728818] Shao, Feng, 2021-04-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9710295
summation	[Summation:9710299] The transcription factor interferon regulatory factor 2 (IRF...

(hasEvent)	[Pathway:R-HSA-5620971] Pyroptosis
(precedingEvent)	[BlackBoxEvent:R-HSA-9710294] GSDMD expression mediated by IRF2, IRF1

Cite Us!