Reactome | GSDME oligomerizes

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GSDME oligomerizes Show undefined attributes

authored	[InstanceEdit:9706708] Shamovsky, Veronica, 2020-11-09
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9710266] Shamovsky, Veronica, 2020-12-25
dbId	9710254
displayName	GSDME oligomerizes
edited	[InstanceEdit:9715950] Shorser, Solomon, 2021-02-17
eventOf	[Pathway:R-HSA-5620971] Pyroptosis - Homo sapiens
input	[Complex:R-HSA-9647679] GSDME (1-270):PIPs [plasma membrane] 2 × [EntityWithAccessionedSequence:R-HSA-9647689] GSDME(1-270) [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9689630] Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation [LiteratureReference:9647674] Pore-forming activity and structural autoinhibition of the gasdermin family
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	GSDME oligomerizes
orthologousEvent	[Reaction:R-BTA-9710254] GSDME oligomerizes - Bos taurus [Reaction:R-GGA-9710254] GSDME oligomerizes - Gallus gallus [Reaction:R-XTR-9710254] GSDME oligomerizes - Xenopus tropicalis [Reaction:R-DRE-9710254] GSDME oligomerizes - Danio rerio [Reaction:R-SSC-9710254] GSDME oligomerizes - Sus scrofa [Reaction:R-CFA-9710254] GSDME oligomerizes - Canis familiaris [Reaction:R-RNO-9710254] GSDME oligomerizes - Rattus norvegicus [Reaction:R-MMU-9710254] GSDME oligomerizes - Mus musculus
output	[Complex:R-HSA-9710248] GSDME oligomer:PIP [plasma membrane]
precedingEvent	[Reaction:R-HSA-9647660] GSDME (1-270) binds PIPs - Homo sapiens
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9715448] Kanneganti, Thirumala-Devi, 2021-02-17 [InstanceEdit:9715449] D'Eustachio, Peter, 2021-02-17 [InstanceEdit:9728818] Shao, Feng, 2021-04-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9710254
summation	[Summation:9710258] The N?terminal fragment of gasdermin E (GSDME(1-270)) produc...

Referrals

(hasEvent)

[Pathway:R-HSA-5620971] Pyroptosis