Reactome | BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51

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BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51 Show undefined attributes

authored	[InstanceEdit:9709263] Orlic-Milacic, Marija, 2020-12-11
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9709572] Orlic-Milacic, Marija, 2020-12-15
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9709571
disease	[Disease:1500689] cancer
displayName	BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51
edited	[InstanceEdit:9763742] Orlic-Milacic, Marija, 2022-02-04
entityFunctionalStatus	[EntityFunctionalStatus:9763399] loss_of_function of BRCA2 mutants (RAD51 binding):SEM1 [nucleoplasm]
eventOf	[Pathway:R-HSA-9709570] Impaired BRCA2 binding to RAD51 - Homo sapiens
input	[Complex:R-HSA-5685162] ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] [Complex:R-HSA-9763400] BRCA2 mutants (RAD51 binding):SEM1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5685231] p-T309-RAD51 [nucleoplasm]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9709578] Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control [LiteratureReference:9763128] Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats [LiteratureReference:9763127] Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51
normalReaction	[Reaction:R-HSA-5693561] RAD51 binds BRCA2 at resected DNA DSBs
releaseDate	2022-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9763679] Liu, Jie, 2022-01-26 [InstanceEdit:9763678] Le, Hang Phuong, 2022-01-26 [InstanceEdit:9763681] Heyer, Wolf-Dietrich, 2022-01-26
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9709571
summation	[Summation:9709576] BRCA2 contains 8 BRC repeats in its middle region, which are...

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[Pathway:R-HSA-9709570] Impaired BRCA2 binding to RAD51

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