Reactome | p-Y483 BACH1 translocates from the nucleoplasm to the cytosol

Schema > BlackBoxEvent > Entries

p-Y483 BACH1 translocates from the nucleoplasm to the cytosol Show undefined attributes

authored	[InstanceEdit:9707997] Stephan, Ralf, 2020-11-23
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9708449] Stephan, Ralf, 2020-11-30
dbId	9708466
displayName	p-Y483 BACH1 translocates from the nucleoplasm to the cytosol
edited	[InstanceEdit:9707997] Stephan, Ralf, 2020-11-23
eventOf	[Pathway:R-HSA-9708530] Regulation of BACH1 activity - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9762202] p-Y483 BACH1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9708555] Antioxidant-induced phosphorylation of tyrosine 486 leads to rapid nuclear export of Bach1 that allows Nrf2 to bind to the antioxidant response element and activate defensive gene expression [LiteratureReference:9708547] Redox regulation of the transcriptional repressor Bach1
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	p-Y483 BACH1 translocates from the nucleoplasm to the cytosol BACH1 gets shuttled out of the nucleus
orthologousEvent	[BlackBoxEvent:R-MMU-9708466] p-Y483 BACH1 translocates from the nucleoplasm to the cytosol - Mus musculus [BlackBoxEvent:R-DME-9708466] p-Y483 BACH1 translocates from the nucleoplasm to the cytosol - Drosophila melanogaster [BlackBoxEvent:R-GGA-9708466] p-Y483 BACH1 translocates from the nucleoplasm to the cytosol - Gallus gallus [BlackBoxEvent:R-XTR-9708466] p-Y483 BACH1 translocates from the nucleoplasm to the cytosol - Xenopus tropicalis [BlackBoxEvent:R-DRE-9708466] p-Y483 BACH1 translocates from the nucleoplasm to the cytosol - Danio rerio [BlackBoxEvent:R-SSC-9708466] p-Y483 BACH1 translocates from the nucleoplasm to the cytosol - Sus scrofa [BlackBoxEvent:R-BTA-9708466] p-Y483 BACH1 translocates from the nucleoplasm to the cytosol - Bos taurus [BlackBoxEvent:R-CFA-9708466] p-Y483 BACH1 translocates from the nucleoplasm to the cytosol - Canis familiaris [BlackBoxEvent:R-RNO-9708466] p-Y483 BACH1 translocates from the nucleoplasm to the cytosol - Rattus norvegicus
output	[EntityWithAccessionedSequence:R-HSA-9762206] p-Y483 BACH1 [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9762209] BACH1 is phosphorylated at tyrosine 483 - Homo sapiens
regulatedBy	[PositiveRegulation:9620522] Positive regulation by 'ROS [nucleoplasm]'
regulationReference	[RegulationReference:9708540] Positive regulation by 'ROS [nucleoplasm]' Antioxidant-induced phosphorylation of tyrosine 486 leads to rapid nuclear export of Bach1 that allows Nrf2 to bind to the antioxidant response element and activate defensive gene expression
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9713327] Somers, Julia, 2021-01-23
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9708466
summation	[Summation:9708461] Transcription regulator protein BACH1, the negative regulato...
updateTrackers	[UpdateTracker:9846754] Update Tracker - [BlackBoxEvent:9708466] p-Y483 BACH1 translocates from the nucleoplasm to the cytosol - v84:[modifyText] [UpdateTracker:9775201] Update Tracker - [BlackBoxEvent:9708466] p-Y486 BACH1 translocates from the nucleoplasm to the cytosol - v80:[addLiteratureReference, add_removeInput, add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9846754] Update Tracker - [BlackBoxEvent:9708466] p-Y483 BACH1 translocates from the nucleoplasm to the cytosol - v84:[modifyText] [UpdateTracker:9775201] Update Tracker - [BlackBoxEvent:9708466] p-Y486 BACH1 translocates from the nucleoplasm to the cytosol - v80:[addLiteratureReference, add_removeInput, add_removeOutput]
(hasEvent)	[Pathway:R-HSA-9708530] Regulation of BACH1 activity

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