Reactome | CYP19A1 binds Aromatase inhibitors

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CYP19A1 binds Aromatase inhibitors Show undefined attributes

authored	[InstanceEdit:9724665] Jassal, Bijay, 2021-03-25
category	binding
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9707359] Jassal, Bijay, 2020-11-16
dbId	9707353
displayName	CYP19A1 binds Aromatase inhibitors
edited	[InstanceEdit:9757169] Jassal, Bijay, 2021-10-27 [InstanceEdit:9773839] Matthews, Lisa, 2022-05-10
eventOf	[Pathway:R-HSA-193144] Estrogen biosynthesis - Homo sapiens
input	[DefinedSet:R-ALL-9707314] Aromatase inhibitors [cytosol] [EntityWithAccessionedSequence:R-HSA-193137] CYP19A1 [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9707335] Inactivation of aromatase in vitro by 4-hydroxy-4-androstene-3,17-dione and 4-acetoxy-4-androstene-3,17-dione and sustained effects in vivo [LiteratureReference:9707360] Highly selective inhibition of estrogen biosynthesis by CGS 20267, a new non-steroidal aromatase inhibitor [LiteratureReference:9707318] Approval summary: letrozole in the treatment of postmenopausal women with advanced breast cancer [LiteratureReference:9707346] An overview of the pharmacology and pharmacokinetics of the newer generation aromatase inhibitors anastrozole, letrozole, and exemestane [LiteratureReference:9707354] HPMA copolymer-aminoglutethimide conjugates inhibit aromatase in MCF-7 cell lines [LiteratureReference:9707355] Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	CYP19A1 binds Aromatase inhibitors
orthologousEvent	[Reaction:R-CEL-9707353] CYP19A1 binds Aromatase inhibitors - Caenorhabditis elegans [Reaction:R-DME-9707353] CYP19A1 binds Aromatase inhibitors - Drosophila melanogaster [Reaction:R-GGA-9707353] CYP19A1 binds Aromatase inhibitors - Gallus gallus [Reaction:R-XTR-9707353] CYP19A1 binds Aromatase inhibitors - Xenopus tropicalis [Reaction:R-DRE-9707353] CYP19A1 binds Aromatase inhibitors - Danio rerio [Reaction:R-SSC-9707353] CYP19A1 binds Aromatase inhibitors - Sus scrofa [Reaction:R-BTA-9707353] CYP19A1 binds Aromatase inhibitors - Bos taurus [Reaction:R-CFA-9707353] CYP19A1 binds Aromatase inhibitors - Canis familiaris [Reaction:R-RNO-9707353] CYP19A1 binds Aromatase inhibitors - Rattus norvegicus [Reaction:R-MMU-9707353] CYP19A1 binds Aromatase inhibitors - Mus musculus
output	[Complex:R-HSA-9707321] CYP19A1:Aromatase inhibitors [endoplasmic reticulum membrane]
releaseDate	2022-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9767610] Huddart, Rachel, 2022-03-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9707353
summation	[Summation:9707323] CYP19A1 (aromatase) is the enzyme that catalyses a key aroma...

Referrals

(hasEvent)

[Pathway:R-HSA-193144] Estrogen biosynthesis

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