Reactome | Active FLT3 binds to SLA2

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Active FLT3 binds to SLA2 Show undefined attributes

authored	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9706324] Rothfels, Karen, 2020-11-04
dbId	9706323
displayName	Active FLT3 binds to SLA2
edited	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
eventOf	[Pathway:R-HSA-9706369] Negative regulation of FLT3 - Homo sapiens
input	[Complex:R-HSA-9604751] Active FLT3 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-9706161] SLA2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9706142] Src-like adaptor protein 2 (SLAP2) binds to and inhibits FLT3 signaling [LiteratureReference:9706109] Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling [LiteratureReference:9697839] FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications
maxDepth	1
modified	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
name	Active FLT3 binds to SLA2
orthologousEvent	[Reaction:R-BTA-9706323] Active FLT3 binds to SLA2 - Bos taurus [Reaction:R-CFA-9706323] Active FLT3 binds to SLA2 - Canis familiaris [Reaction:R-MMU-9706323] Active FLT3 binds to SLA2 - Mus musculus
output	[Complex:R-HSA-9706273] active FLT3:SLA2 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9604767] FLT3LG dimer:FLT3 dimer autophosphorylates - Homo sapiens
releaseDate	2020-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9706323
summation	[Summation:9706322] SRC-like adaptor protein 2 (SLA2, also known as SLAP2) binds...

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(hasEvent)

[Pathway:R-HSA-9706369] Negative regulation of FLT3

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