Reactome | Active FLT3 binds to ABL2

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Active FLT3 binds to ABL2 Show undefined attributes

authored	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9706289] Rothfels, Karen, 2020-11-04
dbId	9706287
displayName	Active FLT3 binds to ABL2
edited	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
eventOf	[Pathway:R-HSA-9706369] Negative regulation of FLT3 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-375998] ABL2 [cytosol] [Complex:R-HSA-9604751] Active FLT3 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9706052] ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	Active FLT3 binds to ABL2
orthologousEvent	[Reaction:R-XTR-9706287] Active FLT3 binds to ABL2 - Xenopus tropicalis [Reaction:R-SSC-9706287] Active FLT3 binds to ABL2 - Sus scrofa [Reaction:R-BTA-9706287] Active FLT3 binds to ABL2 - Bos taurus [Reaction:R-CFA-9706287] Active FLT3 binds to ABL2 - Canis familiaris [Reaction:R-MMU-9706287] Active FLT3 binds to ABL2 - Mus musculus
output	[Complex:R-HSA-9706249] active FLT3:ABL2 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9604767] FLT3LG dimer:FLT3 dimer autophosphorylates - Homo sapiens
releaseDate	2020-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9706287
summation	[Summation:9706288] The Abelson (ABL) family of non-receptor tyrosine kinase 2 (...

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[Pathway:R-HSA-9706369] Negative regulation of FLT3

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